What is the NOAEL for Beta carotene?
Beta carotene has 100 NOAEL studies in the database. The lowest reported value is 0.2 mg/kg bw/day. Source: INCHEM_WHO_jecfa_jecmono_v1020je01.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Beta carotene
Also known as: trans-beta-Carotene, beta-Carotene, EC No.: 230-636-6, C.I. 40800, Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethyl-, (all-E)- (+15 more)
CAS 7235-40-7
Beta carotene (CAS 7235-40-7) is a chemical substance. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
15
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Beta carotene
CAS Number
7235-40-7
DTXSID
DTXSID3020253
Molecular Formula
C40H56
InChI Key
OENHQHLEOONYIE-JLTXGRSLSA-N
Monoisotopic Mass
536.438202
Synonyms
trans-beta-Carotenebeta-CaroteneEC No.: 230-636-6C.I. 40800Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethyl-, (all-E)-Diet,beta-carotene supplementationEINECS 230-636-6Natural Yellow 261,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene), (all E)-BetacarotenoBetacarotenumKarotin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
DyeSoftener and conditionerFlavouring and nutrientFragrancePharmaceuticalProcessing aids not otherwise specifiedAntioxidantSurface modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; Personal care | European Commission | CosIng |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-0.20.2 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-0.20.2 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =0.28 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =0.28 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =0.28 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =0.28 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | - | Rat | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | - | Rat | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-11 | mg/kg bw/day | ADI | - | Pig | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-11 | mg/kg bw/day | ADI | - | Pig | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-11 | mg/kg bw/day | ADI | - | Pig | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-11 | mg/kg bw/day | ADI | - | Pig | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | dermal | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | dermal | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | dermal | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | dermal | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-44 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-44 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| 01YAE03M7J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01YAE03M7J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01YAE03M7J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01YAE03M7J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <=15 | mg/day | LEL | oral | Human | ToxValDB_EFSA |
| >=20 | mg/day | LEL | oral | Human | ToxValDB_EFSA |
| =6.5 | g/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =6.5 | g/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =10 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =10 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =13 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =13 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =13 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =13 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =14 | mg/kg bw/day | NOAEL | dermal | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =14 | mg/kg bw/day | NOAEL | dermal | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =14 | mg/kg bw/day | NOAEL | dermal | - | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =14 | mg/kg bw/day | NOAEL | dermal | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =30 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =30 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =30 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =30 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v78je01 |
| =50 | mg/kg bw/day | NOAEL | oral | Human; Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =50 | mg/kg bw/day | NOAEL | oral | Human; Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
| =64 | mg/kg bw/day | NOAEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v1020je01 |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | β,β-carotene | 230-636-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BETA CAROTENE
ChEMBL Phase
4
Adverse Events
1526
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E160a — ADI: 5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Beta carotene?
Beta carotene appears on 12 regulatory/inventory lists including IFRA Transparency, Australia; Food and drug - smoking-related products, Europe; Personal care, and 9 more. Source: EPA CPDat.
Is Beta carotene used in cosmetics?
Yes, Beta carotene is also indexed as a cosmetic ingredient under the name CI 75130 (Beta-Carotene). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Beta carotene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Beta carotene used outside industrial chemicals?
Beta carotene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.