What is the NOAEL for Thiamine hydrochloride?
Thiamine hydrochloride has 36 NOAEL studies in the database. The lowest reported value is 11 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Thiamine hydrochloride
Also known as: 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride monohydrochloride, Betabion hydrochloride, Bevitex, Bithiamin, EINECS 200-641-8 (+8 more)
CAS 67-03-8
Thiamine hydrochloride (CAS 67-03-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
36
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Thiamine hydrochloride
CAS Number
67-03-8
DTXSID
DTXSID0040622
Molecular Formula
C12H17N4OS.2ClH
InChI Key
DPJRMOMPQZCRJU-UHFFFAOYSA-M
Monoisotopic Mass
337.065663
Synonyms
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride monohydrochlorideBetabion hydrochlorideBevitexBithiaminEINECS 200-641-8FEMA No. 3322NSC 36226Vitamin B hydrochlorideVitamin b(sub 1) hydrochlorideThiamine HClUNII-M572600E5PThiaminum hydrochloricum
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
DeodorizerSoftener and conditionerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 36 of 36 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =11 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| M572600E5P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M572600E5P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M572600E5P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M572600E5P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3710 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =7870 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =9136 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =19400 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =19670 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 7.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =36 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =36 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.29 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =0.29 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =0.92 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =0.92 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =1.2 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =1.2 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =5.1 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =5.1 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =8.6 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =8.6 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =11 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =11 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =24 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =24 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =36 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =36 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =50 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =50 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =290 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
| =290 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je12 |
Showing 36 of 36 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Thiamine hydrochloride | 200-641-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
THIAMINE HYDROCHLORIDE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Thiamine hydrochloride?
Thiamine hydrochloride appears on 5 regulatory/inventory lists including Europe; supplements, Europe; food_additive; supplements, Europe, and 2 more. Source: EPA CPDat.
Is Thiamine hydrochloride used in cosmetics?
Yes, Thiamine hydrochloride is also indexed as a cosmetic ingredient under the name Thiamine HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Thiamine hydrochloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Thiamine hydrochloride used outside industrial chemicals?
Thiamine hydrochloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.