EFSA toxicology reference values
Thiamine hydrochloride
SOURCE
efsa openfoodtox 3 0 export repository
Thiamine hydrochloride (CAS 67-03-8). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
Thiamine hydrochloride is a cannabis analyte contaminant represented in the cannabis public dataset.
CAS 67-03-8
Cannabis Analyte
Substance Identity
Analyte identity and classification used for this cannabis substance page.
SOURCE
efsa substances
Analyte name
Thiamine hydrochloride
CAS number
67-03-8
Contaminant class
Cannabis Analyte
Contaminant Class Badge
Color-coded cannabis class signal for scanning pesticide, metal, solvent, mycotoxin, and potency pages.
SOURCE
State Cannabis Regulations
Cannabis Analyte
Cannabis contaminant class used to group state testing rows.
Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
SOURCE
cannabis page data
Quality score
2
thin
Jurisdictions
0
No state rows
Lab/analyte rows
0
0 failed (-)
Potency samples
0
67-03-8
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
SOURCE
efsa openfoodtox 3 0 export repository
Thiamine hydrochloride
CAS 67-03-8 / mono-constituent substance
C12H18Cl2N4OS / 6 dossier(s)
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
SOURCE
efsa openfoodtox 3 0 export repository
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| TTC Cramer Class II | 9 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class II | 9 µg/kg bw/day | consumers | - | - |
| margin of safety | >500 other: | consumers | f2908844-4801-40c4-9e5e-6da547c7233b | - |
| margin of safety | >500 other: | consumers | e9304bf2-623b-4d70-8eba-a7e64bd57b48 | - |
| margin of safety | ca.1,000 other: | other: | - | - |
| margin of safety | 1,000 other: | other: | - | - |
| margin of safety | ca.1,000 other: | other: | - | - |
| margin of safety | 1,000 other: | other: | - | - |
| margin of safety | ca.1,000 other: | other: | - | - |
| margin of safety | 1,000 other: | other: | - | - |
| margin of safety | ca.1,000 other: | other: | - | - |
| margin of safety | ca.1,000 other: | other: | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
SOURCE
efsa openfoodtox 3 0 export repository
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| sub-chronic toxicity: oral | rat | oral: feed | 36 other: | - |
| sub-chronic toxicity: oral | rat | oral: feed | 36 other: | - |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 12 compounds belonging to chemical group 29 (thiazoles, thiophene and thiazoline). |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) was asked to deliver a scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the CEF Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC and its consecutive amendments. In Flavouring Group Evaluation 76 (FGE.76), the EFSA considered 26 sulphur-containing heterocyclic compounds evaluated by the JECFA at its 59th meeting. Since publication of FGE.76, one substance, thiazole [FL-no: 15.028], is no longer supported by Industry for use as a flavouring substance in Europe and will therefore not be considered any further. The present revision is made due to inclusion of one additional substance, 5-methyl-2-thiophenecarbaldehyde [FL-no: 15.004], cleared for genotoxicity concern in FGE.224. Additionally, new toxicity data have become available for 5,6- dihydro-2,4,6-tris(2-methylpropyl)-4H-1,3,5-dithiazine [FL-no: 15.113]. Therefore, the present revision of FGE.76, FGE.76Rev1, considers 26 flavouring substances evaluated by the JECFA. The Panel concluded that all 26 Register substances in the JECFA flavouring group of sulphurcontaining heterocyclic compounds are structurally related to the 59 thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in the Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3). |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on sources of vitamin B1 added for nutritional purposes to food supplements. |
| Carcinogenicity_EU_PPP | - | - | - | EFSA shall deliver an opinion on the safety for the target animal(s), consumer, user and the environment and the efficacy of vitamin B1 in the form of thiamine hydrochloride and thiamine mononitrate. |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular the Scientific Panel is requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC, and its consecutive amendments. The present consideration concerns 26 sulphur-containing heterocyclic compounds evaluated by the JECFA (59th meeting) and will be considered in relation to the European Food Safety Authority (EFSA) evaluation of thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated in the Flavouring Group Evaluation 21 (FGE.21). The Panel concluded that all 26 Register substances in the JECFA flavouring group of sulphur-containing heterocyclic compounds are structurally related to the 54 thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in the Flavouring Group Evaluation 21 (FGE.21). |
| Carcinogenicity_EU_PPP | - | - | - | EFSA shall deliver an opinion on the safety for the target animal(s), consumer, user and the environment and the efficacy of vitamin B1 in the form of thiamine hydrochloride and thiamine mononitrate. |
| Genetic Toxicity | - | - | - | EFSA shall deliver an opinion on the safety for the target animal(s), consumer, user and the environment and the efficacy of vitamin B1 in the form of thiamine hydrochloride and thiamine mononitrate. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular the Scientific Panel is requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC, and its consecutive amendments. The present consideration concerns 26 sulphur-containing heterocyclic compounds evaluated by the JECFA (59th meeting) and will be considered in relation to the European Food Safety Authority (EFSA) evaluation of thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated in the Flavouring Group Evaluation 21 (FGE.21). The Panel concluded that all 26 Register substances in the JECFA flavouring group of sulphur-containing heterocyclic compounds are structurally related to the 54 thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in the Flavouring Group Evaluation 21 (FGE.21). |
| Genetic Toxicity | - | - | - | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 12 compounds belonging to chemical group 29 (thiazoles, thiophene and thiazoline). |
| Genetic Toxicity | - | - | - | Following a request from the European Commission, the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) was asked to deliver a scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the CEF Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC and its consecutive amendments. In Flavouring Group Evaluation 76 (FGE.76), the EFSA considered 26 sulphur-containing heterocyclic compounds evaluated by the JECFA at its 59th meeting. Since publication of FGE.76, one substance, thiazole [FL-no: 15.028], is no longer supported by Industry for use as a flavouring substance in Europe and will therefore not be considered any further. The present revision is made due to inclusion of one additional substance, 5-methyl-2-thiophenecarbaldehyde [FL-no: 15.004], cleared for genotoxicity concern in FGE.224. Additionally, new toxicity data have become available for 5,6- dihydro-2,4,6-tris(2-methylpropyl)-4H-1,3,5-dithiazine [FL-no: 15.113]. Therefore, the present revision of FGE.76, FGE.76Rev1, considers 26 flavouring substances evaluated by the JECFA. The Panel concluded that all 26 Register substances in the JECFA flavouring group of sulphurcontaining heterocyclic compounds are structurally related to the 59 thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in the Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3). |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
SOURCE
core public cross-reference
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
SOURCE
page FAQ dataset
What is the regulatory limit for Thiamine hydrochloride in cannabis?
Thiamine hydrochloride does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for Thiamine hydrochloride?
Thiamine hydrochloride does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for Thiamine hydrochloride?
Thiamine hydrochloride has 19 EFSA OpenFoodTox reference value rows in the cannabis database, including TTC Cramer Class II, margin of safety.
Is Thiamine hydrochloride also regulated in cosmetics or food?
Thiamine hydrochloride has a cosmetics ingredient cross-reference with EU status permitted. EFSA food/toxicology context is available on this page.