What is the NOAEL for Calcium disodium ethylenediaminetetraacetate?
Calcium disodium ethylenediaminetetraacetate has 16 NOAEL studies in the database. The lowest reported value is 2.5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium disodium ethylenediaminetetraacetate
Also known as: Calciate(2-), [[N,N'-1,2-ethanediylbis[N-[(carboxy-.kappa.O)methyl]glycinato-.kappa.N,.kappa.O]](4-)]-, disodium, (OC-6-21)-, Calciate(2-), [[N,N′-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N′,O,O′,ON,ON′]-, disodium, (OC-6-21)-, Calciate(2-), [(ethylenedinitrilo)tetraacetato]-, disodium, Acetic acid, (ethylenedinitrilo)tetra-, calcium disodium salt, Antalin (+15 more)
CAS 62-33-9
Calcium disodium ethylenediaminetetraacetate (CAS 62-33-9) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Calcium disodium ethylenediaminetetraacetate
CAS Number
62-33-9
DTXSID
DTXSID2036409
Molecular Formula
C10H16N2O8.Ca.2Na
InChI Key
SHWNNYZBHZIQQV-UHFFFAOYSA-J
Monoisotopic Mass
378.032795
Synonyms
Calciate(2-), [[N,N'-1,2-ethanediylbis[N-[(carboxy-.kappa.O)methyl]glycinato-.kappa.N,.kappa.O]](4-)]-, disodium, (OC-6-21)-Calciate(2-), [[N,N′-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N′,O,O′,ON,ON′]-, disodium, (OC-6-21)-Calciate(2-), [(ethylenedinitrilo)tetraacetato]-, disodiumAcetic acid, (ethylenedinitrilo)tetra-, calcium disodium saltAntalinCalciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',O(N),O(N'))-, disodium, (OC-6-21)-Calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',ON,ON'), disodium, (OC-6-21)-Calciedetate de sodiumCalcium disodium ethylendiaminetetraacetateCalcium-EDTAChelatonDinatrium calcium edeticum
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
51 records
Chelating agentStabilizing agentPreservativeFragranceProcessing aids not otherwise specifiedFlavouring and nutrientAntioxidantDyeBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=2.5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =2.5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =2.5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =30 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8U5D034955 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8U5D034955 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8U5D034955 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8U5D034955 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2750 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >250 | mg/kg bw/day | NOAEC | oral | Rat | ToxValDB_ECHA_IUCLID |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=338 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| 1340 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium calcium edetate | 200-529-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
EDETATE CALCIUM DISODIUM ANHYDROUS
ChEMBL Phase
4
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E385 — ADI: 2.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Calcium disodium ethylenediaminetetraacetate?
Calcium disodium ethylenediaminetetraacetate appears on 5 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is Calcium disodium ethylenediaminetetraacetate used in cosmetics?
Yes, Calcium disodium ethylenediaminetetraacetate is also indexed as a cosmetic ingredient under the name Calcium Disodium EDTA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium disodium ethylenediaminetetraacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium disodium ethylenediaminetetraacetate used outside industrial chemicals?
Calcium disodium ethylenediaminetetraacetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.