What is the NOAEL for Folic acid?
Folic acid has 13 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Folic acid
Also known as: L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, Acfol, N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid, Antianemia factor, EINECS 200-419-0 (+14 more)
CAS 59-30-3
Folic acid (CAS 59-30-3) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Folic acid
CAS Number
59-30-3
DTXSID
DTXSID0022519
Molecular Formula
C19H19N7O6
InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N
Monoisotopic Mass
441.139681
Synonyms
L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-AcfolN-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidAntianemia factorEINECS 200-419-0Factor UFolasicFolcysteineFolicoFolinaL-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Softener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 935E97BOY8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 935E97BOY8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 935E97BOY8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 935E97BOY8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0436 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1.5 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 2.6 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3.8 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 92 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Folic acid | 200-419-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
FOLIC ACID
ChEMBL Phase
4
Adverse Events
10140
Bioactivity
9
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Folic acid?
Folic acid appears on 9 regulatory/inventory lists including active_ingredient; Europe; Pesticides, inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 6 more. Source: EPA CPDat.
Is Folic acid used in cosmetics?
Yes, Folic acid is also indexed as a cosmetic ingredient under the name Folic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Folic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Folic acid used outside industrial chemicals?
Folic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.