What is the NOAEL for 20-Hydroxyecdysone?
20-Hydroxyecdysone has 4 NOAEL studies in the database. The lowest reported value is 779A7KPL0Y UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
20-Hydroxyecdysone
Also known as: 20E, BRN 1917578, Commisterone, Crustecdyson, Crustecdysone (+14 more)
CAS 5289-74-7
20-Hydroxyecdysone (CAS 5289-74-7) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB.
View cosmetic safety profile for Cyanotis Arachnoidea Root Extract →
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
20-Hydroxyecdysone
CAS Number
5289-74-7
DTXSID
DTXSID5040388
Molecular Formula
C27H44O7
InChI Key
NKDFYOWSKOHCCO-YPVLXUMRSA-N
Monoisotopic Mass
480.308704
Synonyms
20EBRN 1917578CommisteroneCrustecdysonCrustecdysoneEcdysteron2-beta,3-beta,14,20,22,25-Hexahydroxy-5-beta-cholet-7-en-6-oneIsoinokosteronePolypodine AViticosteroneNSC 629484(+)-Ecdysterone
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 779A7KPL0Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 779A7KPL0Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 779A7KPL0Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 779A7KPL0Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Plant Extract
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
20-HYDROXYECDYSONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
Is 20-Hydroxyecdysone used in cosmetics?
Yes, 20-Hydroxyecdysone is also indexed as a cosmetic ingredient under the name Cyanotis Arachnoidea Root Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 20-Hydroxyecdysone come from?
Safety data is sourced from EPA ToxValDB, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is 20-Hydroxyecdysone used outside industrial chemicals?
20-Hydroxyecdysone also appears in cosmetics, pharmaceutical, food safety databases.