NOAEL Data REACH Registered Cosmetic Ingredient

Hesperidin

Also known as: 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-, 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-, 5-18-05-00218, 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-, BRN 0075140 (+15 more)

CAS 520-26-3

Hesperidin (CAS 520-26-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Hesperidin →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Hesperidin

CAS Number

520-26-3

DTXSID

DTXSID9044328

Molecular Formula

C28H34O15

InChI Key

QUQPHWDTPGMPEX-QJBIFVCTSA-N

Monoisotopic Mass

610.18977

Synonyms

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-5-18-05-002184H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-BRN 00751407-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, (S)-EINECS 208-288-1Glucopyranoside, hesperetin-7 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-Hesperetin, 7-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside)Hesperetin-7-O-rhamnoglucosideHesperidin, (S)-(-)-Hesperidin, (2S)-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Softener and conditionerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
=52.89	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
E750O06Y6O	UNII	FDA UNII substance identifier	-	-	openFDA substances
E750O06Y6O	UNII	FDA UNII substance identifier	-	-	openFDA substances
E750O06Y6O	UNII	FDA UNII substance identifier	-	-	openFDA substances
E750O06Y6O	UNII	FDA UNII substance identifier	-	-	openFDA substances
25	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
30	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
50	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
100	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
150	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
200	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=750	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
3600	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
5000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Hesperidin	208-288-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL HESPERIDIN

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Hesperidin?

Hesperidin has 15 NOAEL studies in the database. The lowest reported value is 52.89 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Hesperidin?

Hesperidin appears on 3 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical. Source: EPA CPDat.

Is Hesperidin used in cosmetics?

Yes, Hesperidin is also indexed as a cosmetic ingredient under the name Hesperidin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hesperidin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Hesperidin used outside industrial chemicals?

Hesperidin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.