What is the NOAEL for Isophytol?
Isophytol has 12 NOAEL studies in the database. The lowest reported value is A831ZI6VIM UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isophytol
Also known as: 1-Hexadecen-3-ol, 3,7,11,15-tetramethyl-, EINECS 208-008-8, 2,6,10,14-Tetramethylhexadec-15-en-14-ol, 2,6,10-Trimethyl-14-vinylpentadecan-14-ol, UNII-A831ZI6VIM
CAS 505-32-8
Isophytol (CAS 505-32-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Tetramethyl-1-hexadecen-3-ol →
Cross-Vertical Regulatory Divergence
Isophytol is classified GHS CMR hazard (H315, H400, H410, H320, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
12
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Isophytol
CAS Number
505-32-8
DTXSID
DTXSID2025474
Molecular Formula
C20H40O
InChI Key
KEVYVLWNCKMXJX-UHFFFAOYSA-N
Monoisotopic Mass
296.307916
Synonyms
1-Hexadecen-3-ol, 3,7,11,15-tetramethyl-EINECS 208-008-82,6,10,14-Tetramethylhexadec-15-en-14-ol2,6,10-Trimethyl-14-vinylpentadecan-14-olUNII-A831ZI6VIM
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| A831ZI6VIM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A831ZI6VIM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A831ZI6VIM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A831ZI6VIM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >8000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >12000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =250 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =250 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB HESS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,7,11,15-tetramethylhexadec-1-en-3-ol | 208-008-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL453797
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isophytol?
Isophytol appears on 4 regulatory/inventory lists including pharmaceutical, IFRA Transparency, Europe, and 1 more. Source: EPA CPDat.
Is Isophytol used in cosmetics?
Yes, Isophytol is also indexed as a cosmetic ingredient under the name Tetramethyl-1-hexadecen-3-ol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isophytol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Isophytol have different safety status in cosmetics vs industrial chemicals?
Isophytol is classified GHS CMR hazard (H315, H400, H410, H320, H361) in the chemicals database but is allowed in EU cosmetics.
Is Isophytol used outside industrial chemicals?
Isophytol also appears in cosmetics, pharmaceutical, cannabis databases.