What is the NOAEL for (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid?
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid has 4 NOAEL studies in the database. The lowest reported value is IBS9D1EU3J UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid
Also known as: 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)-, (2E)-3-(4-Hydroxyphenyl)acrylic acid, 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (E)-, Cinnamic acid, p-hydroxy-, (E)-, (2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid (+14 more)
CAS 501-98-4
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid (CAS 501-98-4) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB.
Cross-Vertical Regulatory Divergence
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid is classified GHS Danger (H301, H311, H314, H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid
CAS Number
501-98-4
DTXSID
DTXSID30901076
Molecular Formula
C9H8O3
InChI Key
NGSWKAQJJWESNS-ZZXKWVIFSA-N
Monoisotopic Mass
164.047344
Synonyms
2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)-(2E)-3-(4-Hydroxyphenyl)acrylic acid2-Propenoic acid, 3-(4-hydroxyphenyl)-, (E)-Cinnamic acid, p-hydroxy-, (E)-(2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid(E)-3-(4-Hydroxyphenyl)-2-propenoic acid(E)-3-(4-Hydroxyphenyl)acrylic acid(E)-4-Hydroxycinnamic acid(E)-p-Coumaric acid(E)-p-Hydroxycinnamic acidNaringeninic acidp-Hydroxy-trans-cinnamic acid
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| IBS9D1EU3J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IBS9D1EU3J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IBS9D1EU3J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IBS9D1EU3J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
COUMARIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
9
Frequently Asked Questions
Is (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid used in cosmetics?
Yes, (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid is also indexed as a cosmetic ingredient under the name Coumaric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid have different safety status in cosmetics vs industrial chemicals?
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid is classified GHS Danger (H301, H311, H314, H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid used outside industrial chemicals?
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid also appears in cosmetics, pharmaceutical databases.