NOAEL Data Cosmetic Ingredient

L-Ascorbic acid

Also known as: Ascorbic acid (vitamin C), Ascorbic acid, L-Ascorbate, Caswell No. 061B, EINECS 200-066-2 (+15 more)

CAS 50-81-7

L-Ascorbic acid (CAS 50-81-7) is a chemical substance. Key regulatory status: 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ILO ICSC.

View cosmetic safety profile for Ascorbic Acid →

SOURCE noael studies public
NOAEL studies
42
SOURCE chemical inventory jurisdictions
Regulatory lists
17
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
L-Ascorbic acid
CAS Number
50-81-7
DTXSID
DTXSID5020106
Molecular Formula
C6H8O6
InChI Key
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Monoisotopic Mass
176.032088
Synonyms
Ascorbic acid (vitamin C)Ascorbic acidL-AscorbateCaswell No. 061BEINECS 200-066-2FEMA No. 2109Hex-2-enonic acid gamma-lactone, L-threo-NCI-C54808L-threo-Hex-2-enonic acid, gamma-lactoneAcidum ascorbicumUNII-PQ6CK8PD0R(+)-Sodium L-ascorbate

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Hazard StatementsNo hazard classification according to GHS criteria
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 43 records
AntioxidantpH regulating agentFragranceDeodorizerSoftener and conditionerPreservativeFlavouring and nutrientPharmaceuticalProcessing aids not otherwise specifiedBiocideChelating agentThickening agentDyeFiller

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records
ListKeywordSource
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
SCIL (9/2019)USEPASafer Chemical Ingredients List
inert_ingredient; PesticidesEPACPCat
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; supplementsEUCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies
ValueUnitEndpointRouteSpeciesSource
PQ6CK8PD0RUNIIFDA UNII substance identifier--openFDA substances
PQ6CK8PD0RUNIIFDA UNII substance identifier--openFDA substances
PQ6CK8PD0RUNIIFDA UNII substance identifier--openFDA substances
PQ6CK8PD0RUNIIFDA UNII substance identifier--openFDA substances
0.26fractionFu-HumanNTP_ICE_adme_parameters
>5000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=11900mg/kg bwLD50oralRatNTP_ICE_acute_oral
=25mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=1250mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=1250mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=1458mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=1458mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
>2560mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
>2560mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=7186mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=7186mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=15000mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=15000mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=5000mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=5000mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
>12788mg/kg bw/dayLOAELoralMouseToxValDB_ToxRefDB
>12788mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=100mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
-unitlessModel Score--NTP_ICE_endocrine
>-mg/kg bw/dayNELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=3750mg/kg bw/dayNELoralMouseToxValDB_ToxRefDB
=3750mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=7500mg/kg bw/dayNELoralMouseToxValDB_ToxRefDB
=7500mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=2500mg/kg bw/dayNOAELoralRatToxValDB_ToxRefDB
=2500mg/kg bw/dayNOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=5%NOELoralRatToxValDB_ECOTOX
=10mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=20mMNOELenvironmentalRatToxValDB_ECOTOX
=40mg/kg bw/dayNOELinjectionMouseToxValDB_ECOTOX
=60mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=100mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=120mg/kg bw/dayNOELinjectionRatToxValDB_ECOTOX
=200mg/kg bw/dayNOELoralMouseToxValDB_ECOTOX
=2000mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
<2400mg/kg bw/dayNOELoralRatToxValDB_HESS
50000ppmTop doseDosed feedMouseNTP_ICE_cancer

Showing 42 of 42 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ASCORBIC ACID
ChEMBL Phase
4
Adverse Events
7867
Bioactivity
15
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E300 — ADI: NOT SPECIFIED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for L-Ascorbic acid?

L-Ascorbic acid has 42 NOAEL studies in the database. The lowest reported value is PQ6CK8PD0R UNII. Source: openFDA substances.

What regulatory lists include L-Ascorbic acid?

L-Ascorbic acid appears on 12 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, children; Europe; Personal care, and 9 more. Source: EPA CPDat.

Is L-Ascorbic acid used in cosmetics?

Yes, L-Ascorbic acid is also indexed as a cosmetic ingredient under the name Ascorbic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for L-Ascorbic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is L-Ascorbic acid used outside industrial chemicals?

L-Ascorbic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.