What is the NOAEL for Diethoxymethane?
Diethoxymethane has 5 NOAEL studies in the database. The lowest reported value is 42.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethoxymethane
Also known as: Formaldehyde diethyl acetal, Ethane, 1,1'-[methylenebis(oxy)]bis-, HEPTANE, 3,5-DIOXA-, 4-01-00-03027, BRN 1697253 (+7 more)
CAS 462-95-3
Diethoxymethane (CAS 462-95-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Diethoxymethane is classified GHS Danger (H225, H315, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Diethoxymethane
CAS Number
462-95-3
DTXSID
DTXSID6052112
Molecular Formula
C5H12O2
InChI Key
KLKFAASOGCDTDT-UHFFFAOYSA-N
Monoisotopic Mass
104.08373
Synonyms
Formaldehyde diethyl acetalEthane, 1,1'-[methylenebis(oxy)]bis-HEPTANE, 3,5-DIOXA-4-01-00-03027BRN 16972531,1-DiethoxymethaneDiethylformal3,5-DioxahepteneEINECS 207-330-6Ethoxymethyl ethyl etherEthylalNSC 6754
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
SolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =42.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 56IT408V5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 56IT408V5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 56IT408V5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 56IT408V5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethoxymethane | 207-330-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Diethoxymethane?
Diethoxymethane appears on 2 regulatory/inventory lists including air; Cleaning products and household care - laundry and fabric treatment; detected; emissions, Europe. Source: EPA CPDat.
Is Diethoxymethane used in cosmetics?
Yes, Diethoxymethane is also indexed as a cosmetic ingredient under the name Ethylal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethoxymethane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Diethoxymethane have different safety status in cosmetics vs industrial chemicals?
Diethoxymethane is classified GHS Danger (H225, H315, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Diethoxymethane used outside industrial chemicals?
Diethoxymethane also appears in cosmetics, cannabis databases.