NOAEL Data Cosmetic Ingredient

3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane]

Also known as: EINECS 255-560-0, 3,4,4a,5,8,8a-Hexahydro-3',7

CAS 41816-03-9

3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] (CAS 41816-03-9) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Hexahydro-dimethylspiromethanonaphthalene-oxirane →

SOURCE noael studies public
NOAEL studies
2
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane]
CAS Number
41816-03-9
DTXSID
DTXSID6052089
Molecular Formula
C14H20O
InChI Key
VKPRTBDRPNWOGL-UHFFFAOYSA-N
Monoisotopic Mass
204.151415
Synonyms
EINECS 255-560-03,4,4a,5,8,8a-Hexahydro-3',7

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
IFRA TransparencyIFRAIFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 2 of 2 studies
ValueUnitEndpointRouteSpeciesSource
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
4unitlessRelative reliability scoreDermalHumanNTP_ICE_skin_sensitization

Showing 2 of 2 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane]?

3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] has 2 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane]?

3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.

Is 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] used in cosmetics?

Yes, 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] is also indexed as a cosmetic ingredient under the name Hexahydro-dimethylspiromethanonaphthalene-oxirane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] have different safety status in cosmetics vs industrial chemicals?

3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] is prohibited in EU cosmetics but has active industrial GHS classifications.

Is 3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] used outside industrial chemicals?

3,4,4a,5,8,8a-Hexahydro-3',7'-dimethylspiro[1,4-methanonaphthalene-2(1H),2'-oxirane] also appears in cosmetics databases.