NOAEL Data REACH Registered Cosmetic Ingredient

(E)-Anethole

Also known as: Benzene, 1-methoxy-4-(1E)-1-propenyl-, trans-Anethole, BRN 0636190, EINECS 224-052-0, FEMA No. 2086 (+15 more)

CAS 4180-23-8

(E)-Anethole (CAS 4180-23-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Anethole →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

(E)-Anethole

CAS Number

4180-23-8

DTXSID

DTXSID9020087

Molecular Formula

C10H12O

InChI Key

RUVINXPYWBROJD-ONEGZZNKSA-N

Monoisotopic Mass

148.088815

Synonyms

Benzene, 1-methoxy-4-(1E)-1-propenyl-trans-AnetholeBRN 0636190EINECS 224-052-0FEMA No. 2086Methoxy-beta-methylstyrene, trans-p-1-p-Methoxyphenylpropene, trans-1-Methoxy-4-(1-propenyl)benzene, (E)-Propenylanisole, p-, (E)-UNII-Q3JEK5DO4KAnethole, trans(E)-1-Methoxy-4-(1-propenyl)benzene

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 26 records

Flavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe	European Commission	Fl@vis
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 31 of 31 studies

Value	Unit	Endpoint	Route	Species	Source
<=2	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=2	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=2	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=10.57	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
Q3JEK5DO4K	UNII	FDA UNII substance identifier	-	-	openFDA substances
Q3JEK5DO4K	UNII	FDA UNII substance identifier	-	-	openFDA substances
Q3JEK5DO4K	UNII	FDA UNII substance identifier	-	-	openFDA substances
Q3JEK5DO4K	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1296	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=50	mg/kg bw/day	LOEL	injection	Mouse	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
>=600	mg/kg bw/day	NOAEC	oral	Rat	ToxValDB_ECHA_IUCLID
<1500	mg/kg bw/day	NOAEC	oral	Rat	ToxValDB_ECHA_IUCLID
4.53	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
125	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
~195	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
225	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
300	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
~300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=300	mg/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>=400	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<=400	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
<=400	mg/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
500	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
<=550	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
690	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
741	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
~780	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 31 of 31 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	(E)-anethole	224-052-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.001% leave-on / 0.01% rinse-off (labeling threshold)

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ANETHOLE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-2 mg/kg bw mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for (E)-Anethole?

(E)-Anethole has 31 NOAEL studies in the database. The lowest reported value is 2 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include (E)-Anethole?

(E)-Anethole appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.

Is (E)-Anethole used in cosmetics?

Yes, (E)-Anethole is also indexed as a cosmetic ingredient under the name Anethole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (E)-Anethole come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is (E)-Anethole used outside industrial chemicals?

(E)-Anethole also appears in cosmetics, pharmaceutical, food safety, cannabis databases.