Also known as: Acrylic acid, 2-methoxyethoxy ester, Acrylic acid, 2-methoxyethyl ester, Ethylene glycol monomethyl ether acrylate, Glycol monomethyl ether acrylate, 2-Methoxyethanol, acrylate (+9 more)
CAS 3121-61-7
2-Methoxyethyl acrylate (CAS 3121-61-7) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H341; H360FD; H331; H302; H314; H318; H317. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
2-Methoxyethyl acrylate is classified GHS Danger (H226, H341, H360FD, H331, H302, H314, H318, H317) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1 | H226; H341; H360FD; H331; H302; H314; H318; H317 | GHS02; GHS08; GHS06; GHS05 | Danger |
Industrial and product-use categories associated with this substance.
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.12 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 45 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| >3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 515K4I683Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 515K4I683Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 515K4I683Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 515K4I683Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.24 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 2.6598 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =404 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =818 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =40 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 42.7 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 15 of 15 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methoxyethyl acrylate | 221-499-3 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
2-Methoxyethyl acrylate (CAS 3121-61-7) is classified under EU CLP Annex VI as Flam. Liq. 3; Muta. 2; Repr. 1B; Acute Tox. 3; Acute Tox. 4; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H226; H341; H360FD; H331; H302; H314; H318; H317. Source: EU CLP Annex VI (ECHA).
2-Methoxyethyl acrylate has 15 NOAEL studies in the database. The lowest reported value is 0.12 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Yes, 2-Methoxyethyl acrylate is also indexed as a cosmetic ingredient under the name Methoxyethyl Acrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2-Methoxyethyl acrylate is classified GHS Danger (H226, H341, H360FD, H331, H302, H314, H318, H317) in the chemicals database but is allowed in EU cosmetics.
2-Methoxyethyl acrylate also appears in cosmetics databases.