What is the GHS hazard classification for 1-Ethyl-2-pyrrolidinone?
1-Ethyl-2-pyrrolidinone (CAS 2687-91-4) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360D. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Ethyl-2-pyrrolidinone
Also known as: 2-Pyrrolidinone, 1-ethyl-, 5-21-06-00328, BRN 0107971, EINECS 220-250-6, N-Ethylpyrrolidinone (+2 more)
CAS 2687-91-4
1-Ethyl-2-pyrrolidinone (CAS 2687-91-4) is a chemical substance with GHS signal word Danger; key hazard signal: H360D. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) →
Cross-Vertical Regulatory Divergence
1-Ethyl-2-pyrrolidinone is prohibited in EU cosmetics but has active industrial GHS classifications (H360D).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
1-Ethyl-2-pyrrolidinone
CAS Number
2687-91-4
DTXSID
DTXSID3044413
Molecular Formula
C6H11NO
InChI Key
ZFPGARUNNKGOBB-UHFFFAOYSA-N
Monoisotopic Mass
113.084064
Synonyms
2-Pyrrolidinone, 1-ethyl-5-21-06-00328BRN 0107971EINECS 220-250-6N-EthylpyrrolidinoneN-EthylpyrrolidoneUNII-H0229SX1CW
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B | H360D | GHS08 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10.05 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =16.75 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| H0229SX1CW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H0229SX1CW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H0229SX1CW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H0229SX1CW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1350 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =200 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =220 | mg/kg bw/day | LOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =80 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-ethylpyrrolidin-2-one | 220-250-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL12221
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What is the NOAEL for 1-Ethyl-2-pyrrolidinone?
1-Ethyl-2-pyrrolidinone has 17 NOAEL studies in the database. The lowest reported value is 10.05 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include 1-Ethyl-2-pyrrolidinone?
1-Ethyl-2-pyrrolidinone appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is 1-Ethyl-2-pyrrolidinone used in cosmetics?
Yes, 1-Ethyl-2-pyrrolidinone is also indexed as a cosmetic ingredient under the name Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Ethyl-2-pyrrolidinone come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Ethyl-2-pyrrolidinone have different safety status in cosmetics vs industrial chemicals?
1-Ethyl-2-pyrrolidinone is prohibited in EU cosmetics but has active industrial GHS classifications (H360D).
Is 1-Ethyl-2-pyrrolidinone used outside industrial chemicals?
1-Ethyl-2-pyrrolidinone also appears in cosmetics, pharmaceutical databases.