NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Acid Red 18, trisodium salt

Also known as: Ponceau 4R, SX purple, C.I. Acid Red 28, Acilan Scarlet V3R, Crimson SX (+14 more)

CAS 2611-82-7

C.I. Acid Red 18, trisodium salt (CAS 2611-82-7) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Acid Red 18 →

Cross-Vertical Regulatory Divergence

C.I. Acid Red 18, trisodium salt is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

C.I. Acid Red 18, trisodium salt

CAS Number

2611-82-7

DTXSID

DTXSID9021213

Molecular Formula

C20H14N2O10S3.3Na

InChI Key

SWGJCIMEBVHMTA-UHFFFAOYSA-K

Monoisotopic Mass

606.950366

Synonyms

Ponceau 4RSX purpleC.I. Acid Red 28Acilan Scarlet V3RCrimson SXEdicol Supra Ponceaux 4 RSEdicol Supra Ponceaux 4RSEINECS 220-036-2New Coccine Extra Conc. A ExportNew Coccine Extra Pure ANew Coccine Red No. 102NSC 4301

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 11 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records

List	Keyword	Source
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - body hygiene - body wash	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bubble bath	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair styling and care - shampoo-dandruff	Danish Environmental Protection Agency	Danish EPA
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 47 of 47 studies

Value	Unit	Endpoint	Route	Species	Source
500	mg/kg bw/day	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
1000	mg/kg	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
=0.7	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.7	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=4	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=24.7	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
Z525CBK9PG	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z525CBK9PG	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z525CBK9PG	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z525CBK9PG	UNII	FDA UNII substance identifier	-	-	openFDA substances
>8000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=10	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
>1	%	NOAEL	oral	rat	SCCNFP_vision_codex
>1	%	NOAEL	oral	rat	SCCNFP_vision_codex
>1	%	NOAEL	oral	rat	SCCNFP_vision_codex
>1	%	NOAEL	oral	rat	SCCNFP_vision_codex
=70	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_EFSA
=70	mg/kg bw/day	NOAEL	oral: feed	Mouse	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=70	mg/kg bw/day	NOAEL	oral: feed	Mouse	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=300	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=300	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=300	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=300	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=1000	mg/kg	NOAEL	-	-	SCCNFP_vision_codex
=1000	mg/kg	NOAEL	-	-	SCCNFP_vision_codex
=1000	mg/kg	NOAEL	-	-	SCCNFP_vision_codex
=1000	mg/kg	NOAEL	-	-	SCCNFP_vision_codex
=1250	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1250	mg/kg bw/day	NOAEL	-	rat	SCCNFP_vision_codex
=1250	mg/kg bw/day	NOAEL	-	rat	SCCNFP_vision_codex
=1250	mg/kg bw/day	NOAEL	-	rat	SCCNFP_vision_codex
=1250	mg/kg bw/day	NOAEL	-	rat	SCCNFP_vision_codex
>8000	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
>8000	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
>8000	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
>8000	mg/kg bw	NOAEL	oral	rat	SCCNFP_vision_codex
=1	mg/kg bw/day	NOEL	oral	Mouse	ToxValDB_ECOTOX
1250	mg/kg bw/day	dermal absorption	-	rat	UnifiedCodex:SCCNFP:beta.noael_studies
500	mg/kg bw/day	irritation	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
>8000	mg/kg bw	irritation	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
300	mg/kg bw/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
500	mg/kg bw/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
>1	%	reproductive toxicity	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies

Showing 47 of 47 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Trisodium 1-(1-naphthylazo)-2-hydroxynaphthalene-4',6,8-trisulphonate	220-036-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

0.5%

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E124 — ADI: 0.7 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for C.I. Acid Red 18, trisodium salt?

C.I. Acid Red 18, trisodium salt has 47 NOAEL studies in the database. The lowest reported value is 0.7 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.

What regulatory lists include C.I. Acid Red 18, trisodium salt?

C.I. Acid Red 18, trisodium salt appears on 8 regulatory/inventory lists including consumer_product; Europe, Europe; Personal care - hair coloring, children; Europe; Personal care, and 5 more. Source: EPA CPDat.

Is C.I. Acid Red 18, trisodium salt used in cosmetics?

Yes, C.I. Acid Red 18, trisodium salt is also indexed as a cosmetic ingredient under the name Acid Red 18. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Red 18, trisodium salt come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does C.I. Acid Red 18, trisodium salt have different safety status in cosmetics vs industrial chemicals?

C.I. Acid Red 18, trisodium salt is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications.

Is C.I. Acid Red 18, trisodium salt used outside industrial chemicals?

C.I. Acid Red 18, trisodium salt also appears in cosmetics, food safety, cannabis databases.