What is the NOAEL for C.I. Direct Red 81 disodium salt?
C.I. Direct Red 81 disodium salt has 8 NOAEL studies in the database. The lowest reported value is 1.492 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Direct Red 81 disodium salt
Also known as: 2-Naphthalenesulfonic acid, 7-(benzoylamino)-4-hydroxy-3-[2-[4-[2-(4-sulfophenyl)diazenyl]phenyl]diazenyl]-, sodium salt (1:2), 2-Naphthalenesulfonic acid, 7-(benzoylamino)-4-hydroxy-3-((4-((4-sulfophenyl)azo)phenyl)azo)-, disodium salt, Disodium 7-benzamido-4-hydroxy-3-((4-((4-sulphonatophenyl)azo)phenyl)azo)naphthalene-2-sulphonat, Solaminrot 4B, Direct Red 81 disodium salt (+15 more)
CAS 2610-11-9
C.I. Direct Red 81 disodium salt (CAS 2610-11-9) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Direct Red 81 disodium salt is prohibited in EU cosmetics but has active industrial GHS classifications.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Direct Red 81 disodium salt
CAS Number
2610-11-9
DTXSID
DTXSID5041726
Molecular Formula
C29H21N5O8S2.2Na
InChI Key
UFUQRRYHIHJMPB-UHFFFAOYSA-L
Monoisotopic Mass
677.062694
Synonyms
2-Naphthalenesulfonic acid, 7-(benzoylamino)-4-hydroxy-3-[2-[4-[2-(4-sulfophenyl)diazenyl]phenyl]diazenyl]-, sodium salt (1:2)2-Naphthalenesulfonic acid, 7-(benzoylamino)-4-hydroxy-3-((4-((4-sulfophenyl)azo)phenyl)azo)-, disodium saltDisodium 7-benzamido-4-hydroxy-3-((4-((4-sulphonatophenyl)azo)phenyl)azo)naphthalene-2-sulphonatSolaminrot 4BDirect Red 81 disodium saltC.I. Direct Red 81Airedale Red KDAizen Primula Red 4BHAmanil Fast Red 8BLAmanil Fast Red 8BLWBelamine Fast Red 8BLBelamine Fast Red 8 BL
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1.492 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =23.51 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 7E49Q56PNB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7E49Q56PNB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7E49Q56PNB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7E49Q56PNB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00004049 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 7-benzamido-4-hydroxy-3-[[4-[(4-sulphonatophenyl)azo]phenyl]azo]naphthalene-2-sulphonate | 220-028-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include C.I. Direct Red 81 disodium salt?
C.I. Direct Red 81 disodium salt appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, banned; Europe; Personal care. Source: EPA CPDat.
Is C.I. Direct Red 81 disodium salt used in cosmetics?
Yes, C.I. Direct Red 81 disodium salt is also indexed as a cosmetic ingredient under the name Direct Red 81. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Direct Red 81 disodium salt come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Direct Red 81 disodium salt have different safety status in cosmetics vs industrial chemicals?
C.I. Direct Red 81 disodium salt is prohibited in EU cosmetics but has active industrial GHS classifications.
Is C.I. Direct Red 81 disodium salt used outside industrial chemicals?
C.I. Direct Red 81 disodium salt also appears in cosmetics databases.