What is the NOAEL for Polyethylene glycol?
Polyethylene glycol has 100 NOAEL studies in the database. The lowest reported value is 0 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Polyethylene glycol
Also known as: PEG, Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, PEG 4, Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, Colyte (+14 more)
CAS 25322-68-3
Polyethylene glycol (CAS 25322-68-3) is a chemical substance. Key regulatory status: REACH registered, 27 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
27
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Polyethylene glycol
CAS Number
25322-68-3
DTXSID
DTXSID4027862
Molecular Formula
C2H6O2
Monoisotopic Mass
62.036779
Synonyms
PEGPoly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-PEG 4Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-Colyte3,6,9,12,15,18,21,24,27,30,33,36,39-Tridecaoxahentetracontane-1,41-diol1,2-Ethanediol homopolymeralpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)alpha-Hydro-omega-hydroxypoly(oxyethylene)NSC 152324Pluracol EUNII-3WJQ0SDW1A
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventBinderProcessing aids not otherwise specifiedLubricating agentHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
27 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| fracking; water | NY Department of Conservation | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=10 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =40.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| - | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 11628IH70O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11628IH70O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11628IH70O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11628IH70O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1212Z7S33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1212Z7S33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1212Z7S33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1212Z7S33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 16P9295IIL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 16P9295IIL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 16P9295IIL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 16P9295IIL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2126FD486L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2126FD486L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2126FD486L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2126FD486L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2L7WA456VA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2L7WA456VA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2L7WA456VA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2L7WA456VA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30IQX730WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30IQX730WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30IQX730WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30IQX730WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H4G04L531 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H4G04L531 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H4G04L531 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3H4G04L531 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3IG9032SAH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3IG9032SAH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3IG9032SAH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3IG9032SAH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3WJQ0SDW1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3WJQ0SDW1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3WJQ0SDW1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3WJQ0SDW1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439X29GCJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439X29GCJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439X29GCJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439X29GCJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QIB4U4CQR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QIB4U4CQR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QIB4U4CQR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QIB4U4CQR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4R4HFI6D95 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4R4HFI6D95 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated | 500-038-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
macrogol
ChEMBL Phase
Not listed
Adverse Events
12812
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E1521 — ADI: 10 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Polyethylene glycol?
Polyethylene glycol appears on 17 regulatory/inventory lists including Europe; Personal care, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 14 more. Source: EPA CPDat.
Is Polyethylene glycol used in cosmetics?
Yes, Polyethylene glycol is also indexed as a cosmetic ingredient under the name PEG-200. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Polyethylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Polyethylene glycol used outside industrial chemicals?
Polyethylene glycol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.