NOAEL Data REACH Registered Cosmetic Ingredient

1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane

Also known as: EINECS 218-320-6, UNII-DR0K5NOJ4R

CAS 2116-84-9

1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane (CAS 2116-84-9) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Phenyl Trimethicone →

SOURCE noael studies public
NOAEL studies
5
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane
CAS Number
2116-84-9
DTXSID
DTXSID6051857
Molecular Formula
C15H32O3Si4
InChI Key
LINXHFKHZLOLEI-UHFFFAOYSA-N
Monoisotopic Mass
372.142851
Synonyms
EINECS 218-320-6UNII-DR0K5NOJ4R

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 24 records
Softener and conditionerDefoamerHumectantAnti-adhesive/cohesiveFlow promoterWetting agent (non-aqueous)Waterproofing agentSurface modifier

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
Canada; pharmaceuticalDrugBankDrugBank
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies
ValueUnitEndpointRouteSpeciesSource
S3QI0ZXT5XUNIIFDA UNII substance identifier--openFDA substances
S3QI0ZXT5XUNIIFDA UNII substance identifier--openFDA substances
S3QI0ZXT5XUNIIFDA UNII substance identifier--openFDA substances
S3QI0ZXT5XUNIIFDA UNII substance identifier--openFDA substances
>1000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane218-320-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane?

1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane has 5 NOAEL studies in the database. The lowest reported value is S3QI0ZXT5X UNII. Source: openFDA substances.

What regulatory lists include 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane?

1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane appears on 2 regulatory/inventory lists including Canada; pharmaceutical, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane used in cosmetics?

Yes, 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane is also indexed as a cosmetic ingredient under the name Phenyl Trimethicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane have different safety status in cosmetics vs industrial chemicals?

1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane is classified GHS Danger (H315, H319, H330, H335) in the chemicals database but is allowed in EU cosmetics.

Is 1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane used outside industrial chemicals?

1,1,1,5,5,5-Hexamethyl-3-phenyl-3-(trimethylsilyloxy)trisiloxane also appears in cosmetics databases.