NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Acid Yellow 23

Also known as: 1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodium salt, C.I. 19140, Tartrazine, Tartrazine yellow 19140, D&C Yellow 5 (+15 more)

CAS 1934-21-0

C.I. Acid Yellow 23 (CAS 1934-21-0) is a chemical substance. Key regulatory status: REACH registered, 41 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for FD&C Yellow No. 5 (CI 19140) →

Cross-Vertical Regulatory Divergence

C.I. Acid Yellow 23 is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics at max 0.11%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

C.I. Acid Yellow 23

CAS Number

1934-21-0

DTXSID

DTXSID1021455

Molecular Formula

C16H12N4O9S2.3Na

InChI Key

ZLWLTDZLUVBSRJ-UHFFFAOYSA-K

Monoisotopic Mass

536.973878

Synonyms

1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodium saltC.I. 19140TartrazineTartrazine yellow 19140D&C Yellow 5A.F. Yellow No. 4Acid Leather Yellow TDye FD and C Yellow No. 5EINECS 217-699-5FD & C Yellow No. 5FD & C Yellow No. 5 tartrazineFD and C Yellow 5

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 41 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - general moisturizing - hand/body lotion	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - body hygiene - body wash	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bubble bath	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care; Europe	Danish EPA	Danish EPA
general_foods	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
Personal care	FDA	United States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 91 studies

Value	Unit	Endpoint	Route	Species	Source
>1000	mg/kg/day	-	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
<=7.5	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=7.5	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=10	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
<=10	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=10	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=372.52	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
I753WB2F1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
I753WB2F1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
I753WB2F1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
I753WB2F1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
>2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
53	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
792	mg/kg bw/day	LOAEL	oral	mouse	COSMOS_DB
8919	mg/kg bw/day	LOAEL	oral	mouse	COSMOS_DB
=1	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=2	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=2.5	% w/v	LOEL	oral	Rat	ToxValDB_ECOTOX
=5	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=7.5	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=10	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
=100	ppm	LOEL	injection	Rat	ToxValDB_ECOTOX
=589	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
>0.7	%	NOAEL	oral	rat	SCCNFP_vision_codex
>0.7	%	NOAEL	oral	rat	SCCNFP_vision_codex
>0.7	%	NOAEL	oral	rat	SCCNFP_vision_codex
>0.7	%	NOAEL	oral	rat	SCCNFP_vision_codex
=5	% diet	NOAEL	oral	Rat	ToxValDB_HPVIS
=5	%	NOAEL	dermal	-	SCCNFP_vision_codex
=5	%	NOAEL	dermal	-	SCCNFP_vision_codex
=5	%	NOAEL	dermal	-	SCCNFP_vision_codex
=5	%	NOAEL	dermal	-	SCCNFP_vision_codex
7.5	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
15	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
500	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=642.8	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
750	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
773	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
984	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=984	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=984	mg/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
1000	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>1000	mg/kg/day	NOAEL	oral	rat	SCCNFP_vision_codex
>1000	mg/kg/day	NOAEL	oral	rat	SCCNFP_vision_codex
>1000	mg/kg/day	NOAEL	oral	rat	SCCNFP_vision_codex
>1000	mg/kg/day	NOAEL	oral	rat	SCCNFP_vision_codex
1064	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=1064	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 50 of 91 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-(4-sulphophenylazo)pyrazole-3-carboxylate	217-699-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

0.11%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL4792247

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E102 — ADI: 7.5 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for C.I. Acid Yellow 23?

C.I. Acid Yellow 23 has 91 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include C.I. Acid Yellow 23?

C.I. Acid Yellow 23 appears on 16 regulatory/inventory lists including Europe; Personal care - hair coloring, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 13 more. Source: EPA CPDat.

Is C.I. Acid Yellow 23 used in cosmetics?

Yes, C.I. Acid Yellow 23 is also indexed as a cosmetic ingredient under the name FD&C Yellow No. 5 (CI 19140). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Yellow 23 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does C.I. Acid Yellow 23 have different safety status in cosmetics vs industrial chemicals?

C.I. Acid Yellow 23 is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics at max 0.11%.

Is C.I. Acid Yellow 23 used outside industrial chemicals?

C.I. Acid Yellow 23 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.