What is the NOAEL for Phenol red?
Phenol red has 10 NOAEL studies in the database. The lowest reported value is 1.1 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
Cosmetic Ingredient
Phenol red
Also known as: 5-19-03-00457, BRN 0326470, EINECS 205-609-7, Phenol, 4,4-(3H-2,1-benzoxathiol-3-ylidene)di-, S-S-dioxide, UNII-I6G9Y0J1OJ (+3 more)
CAS 143-74-8
Phenol red (CAS 143-74-8) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Phenol red
CAS Number
143-74-8
DTXSID
DTXSID8022408
Molecular Formula
C19H14O5S
InChI Key
BELBBZDIHDAJOR-UHFFFAOYSA-N
Monoisotopic Mass
354.056195
Synonyms
5-19-03-00457BRN 0326470EINECS 205-609-7Phenol, 4,4-(3H-2,1-benzoxathiol-3-ylidene)di-, S-S-dioxideUNII-I6G9Y0J1OJ3,3-bis(p-hydroxyphenyl)-3H-2,1-benzoxathiole 1,1-dioxidePSPalpha-hydroxy-alpha,alpha-bis(p-hydroxyphenyl)-o-toluenesulfonic acid gamma-sultone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
pH regulating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 19.3720637514397 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 14.3655609291347 | uM | ACC | - | - | NTP_ICE_endocrine |
| 1.1 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| I6G9Y0J1OJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I6G9Y0J1OJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I6G9Y0J1OJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I6G9Y0J1OJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.142 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0409 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PHENOLSULFONPHTHALEIN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Phenol red?
Phenol red appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Canada; pharmaceutical. Source: EPA CPDat.
Is Phenol red used in cosmetics?
Yes, Phenol red is also indexed as a cosmetic ingredient under the name Phenolsulfonphthalein. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenol red come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenol red used outside industrial chemicals?
Phenol red also appears in cosmetics, pharmaceutical databases.