What is the NOAEL for Nisin?
Nisin has 7 NOAEL studies in the database. The lowest reported value is 0.13 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
Cosmetic Ingredient
Nisin
Also known as: Microgard MG 300, Nisitrol, Novasin, Ambicin N, Delvoplus (+7 more)
CAS 1414-45-5
Nisin (CAS 1414-45-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Lactococcus Ferment Lysate →
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Nisin
CAS Number
1414-45-5
DTXSID
DTXSID20893678
Molecular Formula
C143H230N42O37S7
InChI Key
NVNLLIYOARQCIX-NIMBGDMISA-N
Monoisotopic Mass
3351.545205
Synonyms
Microgard MG 300NisitrolNovasinAmbicin NDelvoplusE 234L-Lysine, L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L-methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto-D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl-L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl-, cyclic (3→7),(8→11),(13→19),(23→26),(25→28)-pentakis(sulfide)NisaplinNisin ANisin(1-34)nisinanisine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Biocide
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.13 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.13 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| <=2 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| EN8XKG133D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EN8XKG133D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EN8XKG133D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EN8XKG133D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E234 — FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Nisin used in cosmetics?
Yes, Nisin is also indexed as a cosmetic ingredient under the name Lactococcus Ferment Lysate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Nisin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Nisin used outside industrial chemicals?
Nisin also appears in cosmetics, food safety, cannabis databases.