What is the NOAEL for Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate?
Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate has 21 NOAEL studies in the database. The lowest reported value is 4.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate
Also known as: 2-02-00-00153, BRN 1722814, cis-3,7-Dimethyl-2,6-octadien-1-ol acetate, 3,7-Dimethyl-2,6-octadienyl acetate, (Z)-, 3,7-Dimethyl-2,6-octadien-1-yl acetate, cis- (+7 more)
CAS 141-12-8
Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate (CAS 141-12-8) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate
CAS Number
141-12-8
DTXSID
DTXSID2047068
Molecular Formula
C12H20O2
InChI Key
HIGQPQRQIQDZMP-FLIBITNWSA-N
Monoisotopic Mass
196.14633
Synonyms
2-02-00-00153BRN 1722814cis-3,7-Dimethyl-2,6-octadien-1-ol acetate3,7-Dimethyl-2,6-octadienyl acetate, (Z)-3,7-Dimethyl-2,6-octadien-1-yl acetate, cis-3,7-Dimethyl-2,6-octadien-1-yl ethanoate, cis-EINECS 205-459-2FEMA No. 2773Geranyl acetate, cis-Neryl ethanoateNSC-72031UNII-OF82IJU18H
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =7.24 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| OF82IJU18H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OF82IJU18H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OF82IJU18H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OF82IJU18H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =345 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =345 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =345 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Neryl acetate | 205-459-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
NERYL ACETATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate?
Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate used in cosmetics?
Yes, Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate is also indexed as a cosmetic ingredient under the name NERYL ACETATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate used outside industrial chemicals?
Cis-3,7-Dimethyl-2,6-octadien-1-yl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.