Also known as: Tetramethylthiouram disulfide, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl-, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl-, Methane, 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetrakis-, Disulfide, bis(dimethylthiocarbamoyl) (+15 more)
CAS 137-26-8
Bis(dimethylaminothiocarbonyl) disulfide (CAS 137-26-8) is a chemical substance with GHS signal word Warning; key hazard signal: H332; H302; H373 **; H315; H319; H317; H400; H410. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Bis(dimethylaminothiocarbonyl) disulfide is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H302, H373, H315, H319, H317, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1990 | Sup 7, 53 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H332; H302; H373 **; H315; H319; H317; H400; H410 | GHS07; GHS08; GHS09 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the thyroid and liver. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| ACGIH | TWA | 0.05 mg/m³ (inhalable fraction and vapor) [2007] | - | 0.05 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | IDLH | 100 mg/m³ | - | 100 | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 15.8495315173844 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 25.92490805 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 1.69650633256529 | uM | ACC | - | - | NTP_ICE_endocrine |
| 13.9488404367794 | uM | ACC | - | - | NTP_ICE_endocrine |
| =0.01 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.01 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.025 | mg/kg bw/day | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.025 | mg/kg bw/day | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 0.1 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.46 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.7 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 3 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.9 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.2 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.06 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| <0.1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 8.1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| <8.9 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 9.11 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.6 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.06 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 8.2 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 10 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 11.5 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 26.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 816 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 1.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6.875 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 7.8125 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 28.75 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 31.25 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.667 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 6.25 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 25 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.118 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 99.5 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 100 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.6 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 6.9 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 51 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 53.2 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.8 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.827 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.89 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.9 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| <0.97 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Thiram | 205-286-2 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Thiram | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Bis(dimethylaminothiocarbonyl) disulfide (CAS 137-26-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H332; H302; H373 **; H315; H319; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
Bis(dimethylaminothiocarbonyl) disulfide has 100 NOAEL studies in the database. The lowest reported value is 3.86e-8 fraction in Human. Source: NTP_ICE_adme_parameters.
Bis(dimethylaminothiocarbonyl) disulfide appears on 8 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; agricultural; Pesticides, active_ingredient; Pesticides, and 5 more. Source: EPA CPDat.
Bis(dimethylaminothiocarbonyl) disulfide is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1990). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Bis(dimethylaminothiocarbonyl) disulfide are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Bis(dimethylaminothiocarbonyl) disulfide is also indexed as a cosmetic ingredient under the name Thiram. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Bis(dimethylaminothiocarbonyl) disulfide is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H302, H373, H315, H319, H317, H400, H410).
Bis(dimethylaminothiocarbonyl) disulfide also appears in cosmetics, pharmaceutical databases.