What is the NOAEL for 4-Hexylresorcinol?
4-Hexylresorcinol has 32 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Hexylresorcinol
Also known as: p-Hexylresorcinol, 1,3-Benzenediol, 4-hexyl-, 4-Hexyl-1,3-benzenediol, Hexylresorcinol, 4-06-00-06048 (+15 more)
CAS 136-77-6
4-Hexylresorcinol (CAS 136-77-6) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-Hexylresorcinol is classified GHS Danger (H302, H315, H319, H335, H360F) in the chemicals database but is allowed in EU cosmetics at max 20%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
32
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-Hexylresorcinol
CAS Number
136-77-6
DTXSID
DTXSID1020699
Molecular Formula
C12H18O2
InChI Key
WFJIVOKAWHGMBH-UHFFFAOYSA-N
Monoisotopic Mass
194.13068
Synonyms
p-Hexylresorcinol1,3-Benzenediol, 4-hexyl-4-Hexyl-1,3-benzenediolHexylresorcinol4-06-00-06048AdroverAntascarinAscaricidAscarinolAscarylBRN 2048312Caprokol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
BiocidePharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 32 of 32 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 16.8984160590701 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 47.6085741 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 10.5243823504332 | uM | ACC | - | - | NTP_ICE_endocrine |
| 63.2174484099999 | uM | ACC | - | - | NTP_ICE_endocrine |
| <=50 | mg/L | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v35je04 |
| <=50 | mg/L | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v35je04 |
| =4 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_EFSA |
| 227 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| R9QTB5E82N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R9QTB5E82N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R9QTB5E82N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R9QTB5E82N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =550 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =62.5 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =62.5 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >125 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| >125 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =250 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =250 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00583 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0687 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.127 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =62.5 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB_ToxRefDB |
| =62.5 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =125 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =125 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =31 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v35je04 |
| =31 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v35je04 |
| <62.5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 125 | mg/kg bw/day | Top dose | Gavage | Rat | NTP_ICE_cancer |
Showing 32 of 32 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-hexylresorcinol | 205-257-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
20%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HEXYLRESORCINOL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
9
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E586 — ADI: 0.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Hexylresorcinol?
4-Hexylresorcinol appears on 2 regulatory/inventory lists including Canada; pharmaceutical, Canada; consumer_product; Substances in Products - Canada (4/2014). Source: EPA CPDat.
Is 4-Hexylresorcinol used in cosmetics?
Yes, 4-Hexylresorcinol is also indexed as a cosmetic ingredient under the name Hexylresorcinol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Hexylresorcinol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Hexylresorcinol have different safety status in cosmetics vs industrial chemicals?
4-Hexylresorcinol is classified GHS Danger (H302, H315, H319, H335, H360F) in the chemicals database but is allowed in EU cosmetics at max 20%.
Is 4-Hexylresorcinol used outside industrial chemicals?
4-Hexylresorcinol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.