Danger GHS02GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Phthalimidoperoxycaproic acid

Also known as: UNII-5OEJ6FAL6C, epsilon-(Phthalimidoperoxy)hexanoic acid, 2H-Isoindole-2-hexaneperoxoic acid, 1,3-dihydro-1,3-dioxo-, 5-(Phthalimido)percaproic acid, 6-(Phthalimidoperoxy)hexanoic acid (+2 more)

CAS 128275-31-0

Phthalimidoperoxycaproic acid (CAS 128275-31-0) is a chemical substance with GHS signal word Danger; key hazard signal: H242; H318; H400. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Phthalimidoperoxycaproic Acid (PAP) →

SOURCE noael studies public
NOAEL studies
7
SOURCE chemical inventory jurisdictions
Regulatory lists
9
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
Phthalimidoperoxycaproic acid
CAS Number
128275-31-0
DTXSID
DTXSID60155848
Molecular Formula
C14H15NO5
InChI Key
UZJGVXSQDRSSHU-UHFFFAOYSA-N
Monoisotopic Mass
277.095023
Synonyms
UNII-5OEJ6FAL6Cepsilon-(Phthalimidoperoxy)hexanoic acid2H-Isoindole-2-hexaneperoxoic acid, 1,3-dihydro-1,3-dioxo-5-(Phthalimido)percaproic acid6-(Phthalimidoperoxy)hexanoic acid6-Phthalimidohexaneperoxoic acidEureco HC

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Org. Perox. D; Eye Dam. 1; Aquatic Acute 1H242; H318; H400GHS02; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Oxidizing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 7 of 7 studies
ValueUnitEndpointRouteSpeciesSource
=1.2mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
5OEJ6FAL6CUNIIFDA UNII substance identifier--openFDA substances
5OEJ6FAL6CUNIIFDA UNII substance identifier--openFDA substances
5OEJ6FAL6CUNIIFDA UNII substance identifier--openFDA substances
5OEJ6FAL6CUNIIFDA UNII substance identifier--openFDA substances
=300mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=100mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 7 of 7 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered6-(phthalimido)peroxyhexanoic acid410-850-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Phthalimidoperoxycaproic acid?

Phthalimidoperoxycaproic acid (CAS 128275-31-0) is classified under EU CLP Annex VI as Org. Perox. D; Eye Dam. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H242; H318; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Phthalimidoperoxycaproic acid?

Phthalimidoperoxycaproic acid has 7 NOAEL studies in the database. The lowest reported value is 1.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Phthalimidoperoxycaproic acid?

Phthalimidoperoxycaproic acid appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Europe; Personal care - oral and dental care - teeth whitener. Source: EPA CPDat.

Is Phthalimidoperoxycaproic acid used in cosmetics?

Yes, Phthalimidoperoxycaproic acid is also indexed as a cosmetic ingredient under the name Phthalimidoperoxycaproic Acid (PAP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phthalimidoperoxycaproic acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Phthalimidoperoxycaproic acid have different safety status in cosmetics vs industrial chemicals?

Phthalimidoperoxycaproic acid is classified GHS Danger (H242, H318, H400) in the chemicals database but is allowed in EU cosmetics.

Is Phthalimidoperoxycaproic acid used outside industrial chemicals?

Phthalimidoperoxycaproic acid also appears in cosmetics databases.