What is the NOAEL for Beta-Pinene?
Beta-Pinene has 14 NOAEL studies in the database. The lowest reported value is 4MS8VHZ1HJ UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Beta-Pinene
Also known as: Bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-, 2(10)-Pinene, 6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptane, (+/-)-β-Pinene, (+/-)-2(10)-Pinene (+15 more)
CAS 127-91-3
Beta-Pinene (CAS 127-91-3) is a chemical substance. Key regulatory status: 33 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, OSHA.
Cross-Vertical Regulatory Divergence
Beta-Pinene is classified GHS Danger (H226, H304, H315, H317, H331, H335, H400, H410) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
33
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Beta-Pinene
CAS Number
127-91-3
DTXSID
DTXSID7027049
Molecular Formula
C10H16
InChI Key
WTARULDDTDQWMU-UHFFFAOYSA-N
Monoisotopic Mass
136.125201
Synonyms
Bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-2(10)-Pinene6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptane(+/-)-β-Pinene(+/-)-2(10)-Pinene(+/-)-6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptaneNopinenNopinenePseudopinenPseudopineneTerebenthenePC 600 (pesticide)
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
1 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 20 ppm [2001] | 20 | - | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
33 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; emissions; Europe; nondetect; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; emissions; Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4MS8VHZ1HJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4MS8VHZ1HJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4MS8VHZ1HJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4MS8VHZ1HJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =4700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =860 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =222 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =222 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =222 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =688 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 14 of 14 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Beta-Pinene?
Beta-Pinene appears on 21 regulatory/inventory lists including air; detected; emissions; Europe; Vehicle - car interior, air; emissions; Europe; nondetect; Vehicle - car interior, Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe, and 18 more. Source: EPA CPDat.
What are the occupational exposure limits for Beta-Pinene?
Occupational exposure limits for Beta-Pinene are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Beta-Pinene used in cosmetics?
Yes, Beta-Pinene is also indexed as a cosmetic ingredient under the name Beta-Pinenes. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Beta-Pinene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Beta-Pinene have different safety status in cosmetics vs industrial chemicals?
Beta-Pinene is classified GHS Danger (H226, H304, H315, H317, H331, H335, H400, H410) in the chemicals database but is restricted in EU cosmetics.
Is Beta-Pinene used outside industrial chemicals?
Beta-Pinene also appears in cosmetics, cannabis databases.