What is the NOAEL for 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one?
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one has 5 NOAEL studies in the database. The lowest reported value is 54PXU8D4R5 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one
Also known as: 1-Penten-3-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, beta methyl ionone, Cetone, beta-, EINECS 204-843-7, FEMA No. 2712 (+7 more)
CAS 127-43-5
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one (CAS 127-43-5) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one
CAS Number
127-43-5
DTXSID
DTXSID6051643
Molecular Formula
C14H22O
InChI Key
LMWNGLDCJDIIBR-UHFFFAOYSA-N
Monoisotopic Mass
206.167065
Synonyms
1-Penten-3-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-beta methyl iononeCetone, beta-EINECS 204-843-7FEMA No. 2712beta-Ionone, methyl-beta-Iraldeinebeta-MethyliononeNSC 1639951-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-1-penten-3-one5-(2,6,6-Trimethyl-1-cyclohexenyl)-4-penten-3-oneUNII-54PXU8D4R5
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
23 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 54PXU8D4R5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 54PXU8D4R5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 54PXU8D4R5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 54PXU8D4R5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one?
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one used in cosmetics?
Yes, 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one is also indexed as a cosmetic ingredient under the name Alpha-Methyl-Beta-Ionone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one have different safety status in cosmetics vs industrial chemicals?
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H411).
Is 1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one used outside industrial chemicals?
1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one also appears in cosmetics, cannabis databases.