What is the NOAEL for Benzethonium chloride?
Benzethonium chloride has 100 NOAEL studies in the database. The lowest reported value is 0 s via Ocular. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzethonium chloride
Also known as: Benzenemethanaminium, N,N-dimethyl-N-(2-(2-(4-(1,1 ,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)-, chloride, Banagerm, Benzethoni chloridum, Benzethonium chloride 1622, Benzethoniumchloride (+15 more)
CAS 121-54-0
Benzethonium chloride (CAS 121-54-0) is a chemical substance. Key regulatory status: REACH registered, 37 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Benzethonium chloride is classified GHS Danger (H301, H302, H314, H318, H400, H410, H315, H319) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
37
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Benzethonium chloride
CAS Number
121-54-0
DTXSID
DTXSID6023810
Molecular Formula
C27H42NO2.ClH
InChI Key
UREZNYTWGJKWBI-UHFFFAOYSA-M
Monoisotopic Mass
448.298232
Synonyms
Benzenemethanaminium, N,N-dimethyl-N-(2-(2-(4-(1,1 ,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)-, chlorideBanagermBenzethoni chloridumBenzethonium chloride 1622BenzethoniumchlorideBenzyldimethyl-p-(1,1,3,3-tetramethylbutyl)phenoxyethoxy-ethylammonium chlorideBenzyldimethyl(2-(2-(p-(1,1,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)ammonium chlorideBenzyldimethyl(2-(2-(4-(1,1,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)ammonium chlorideBZT (VAN)Caswell No. 614Bp-Diisobutyl phenoxyethoxyethyl dimethyl benzylammonium chloride(2-(2-(4-Diisobutylphenoxy)ethoxy)ethyl)dimethylbenzylammonium chloride
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed Causes skin irritation Causes serious eye damage Toxic to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes. The substance is irritating to the skin. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | The substance can be absorbed into the body through the skin and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
BiocideSurfactant (surface active agent)PreservativeDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
37 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; Personal care | European Commission | CosIng |
| pharmaceutical | US International Trade Commission | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Pesticides | National Park Service | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.014 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 3.6 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 3.6 | mg/kg BW/day | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 3.6 | mg/kg BW/day | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 3.6 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 40 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 67 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| PH41D05744 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PH41D05744 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PH41D05744 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PH41D05744 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.38 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| =368 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =0.15 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB_ToxRefDB |
| =0.15 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1.56 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB_ToxRefDB |
| =1.56 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =6.3 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB_ToxRefDB |
| =6.3 | mg/kg bw/day | LEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =12.5 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB_ToxRefDB |
| =12.5 | mg/kg bw/day | LEL | dermal | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1.5 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ToxRefDB |
| =1.5 | mg/kg bw/day | LOAEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =3.13 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ToxRefDB |
| =3.13 | mg/kg bw/day | LOAEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =25 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ToxRefDB |
| =25 | mg/kg bw/day | LOAEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =50 | mg/kg bw/day | LOAEL | dermal | Mouse | ToxValDB_ToxRefDB |
| =50 | mg/kg bw/day | LOAEL | dermal | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =15 | mg/kg bw/day | LOEL | injection | European Rabbit | ToxValDB_ECOTOX |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| >- | mg/kg bw/day | NEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =0.014 | mg/kg bw/day | NOAEL | - | rat | SCCNFP_vision_codex |
| =0.014 | mg/kg bw/day | NOAEL | - | rat | SCCNFP_vision_codex |
| =0.014 | mg/kg bw/day | NOAEL | - | rat | SCCNFP_vision_codex |
| =0.014 | mg/kg bw/day | NOAEL | - | rat | SCCNFP_vision_codex |
| =0.1 | % | NOAEL | dermal | rat | SCCNFP_vision_codex |
| =0.1 | % | NOAEL | dermal | rat | SCCNFP_vision_codex |
| =0.1 | % | NOAEL | dermal | rat | SCCNFP_vision_codex |
| =0.1 | % | NOAEL | dermal | rat | SCCNFP_vision_codex |
| =0.5 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ToxRefDB |
| =0.5 | mg/kg bw/day | NOAEL | dermal | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1 | mg/kg bw/day | NOAEL | oral | rabbit | SCCNFP_vision_codex |
| =1 | mg/kg bw/day | NOAEL | oral | rabbit | SCCNFP_vision_codex |
| =1 | mg/kg bw/day | NOAEL | oral | rabbit | SCCNFP_vision_codex |
| =1 | mg/kg bw/day | NOAEL | oral | rabbit | SCCNFP_vision_codex |
| =3.6 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =3.6 | mg/kg BW/day | NOAEL | - | - | SCCNFP_vision_codex |
| =3.6 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP_vision_codex |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzethonium chloride | 204-479-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
preservative_booster
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BENZETHONIUM CHLORIDE
ChEMBL Phase
2
Adverse Events
347
Bioactivity
32
Frequently Asked Questions
What regulatory lists include Benzethonium chloride?
Benzethonium chloride appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, Europe; Personal care, pharmaceutical, and 5 more. Source: EPA CPDat.
Is Benzethonium chloride used in cosmetics?
Yes, Benzethonium chloride is also indexed as a cosmetic ingredient under the name Benzethonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzethonium chloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Benzethonium chloride have different safety status in cosmetics vs industrial chemicals?
Benzethonium chloride is classified GHS Danger (H301, H302, H314, H318, H400, H410, H315, H319) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Is Benzethonium chloride used outside industrial chemicals?
Benzethonium chloride also appears in cosmetics, pharmaceutical databases.