Benzethonium Chloride
CAS 121-54-0
Benzethonium Chloride (CAS 121-54-0) is a Phase 2 pharmaceutical compound with 20 bioactivity targets and 347 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | Potency | 29778.132352941175 nM | 115 | - |
| - | AC50 | 16461.62213592233 nM | 103 | - |
| - | GI50 | 4171.516833333333 nM | 60 | - |
| - | IC50 | 16721.5308 nM | 50 | - |
| - | Potency | 16299.429166666667 nM | 23 | - |
| - | Ki | 621.595 nM | 20 | - |
| - | MIC | 6.85 ug.mL-1 | 10 | - |
| - | AC50 | 18134.8 nM | 5 | - |
| - | EC50 | 46427.25 nM | 4 | - |
| - | MIC | 261900 nM | 3 | - |
| - | IC50 | 19976.309999999998 nM | 1 | - |
| - | EC50 | 0.01 ug.mL-1 | 1 | - |
| Alpha-2A adrenergic receptor GPCR |
Ki | 5.934 | - | Homo sapiens |
| Potassium voltage-gated channel subfamily H member 2 Ion channel |
Ki | 7.051 | - | Homo sapiens |
| Sodium-dependent serotonin transporter Transporter |
Ki | 5.888 | - | Homo sapiens |
| Sodium-dependent noradrenaline transporter Transporter |
Ki | 6.046 | - | Homo sapiens |
| 5-hydroxytryptamine receptor 2A GPCR |
Ki | 7.432 | - | Homo sapiens |
| 5-hydroxytryptamine receptor 2C GPCR |
Ki | 6.269 | - | Homo sapiens |
| Alpha-2B adrenergic receptor GPCR |
Ki | 6.532 | - | Homo sapiens |
| Muscarinic acetylcholine receptor M1 GPCR |
Ki | 7.004 | - | Homo sapiens |
| Muscarinic acetylcholine receptor M2 GPCR |
Ki | 6.69 | - | Homo sapiens |
| Muscarinic acetylcholine receptor M3 GPCR |
Ki | 7.092 | - | Homo sapiens |
| Muscarinic acetylcholine receptor M4 GPCR |
Ki | 7.444 | - | Homo sapiens |
| Muscarinic acetylcholine receptor M5 GPCR |
Ki | 7.018 | - | Homo sapiens |
| Alpha-2C adrenergic receptor GPCR |
Ki | 6.545 | - | Homo sapiens |
| Sodium-dependent dopamine transporter Transporter |
Ki | 5.965 | - | Homo sapiens |
| Acetylcholinesterase Enzyme |
IC50 | 5.649 | - | Homo sapiens |
| Tyrosine-protein kinase Fyn Kinase |
IC50 | 6.115 | - | Homo sapiens |
| Receptor tyrosine-protein kinase erbB-2 Kinase |
IC50 | 5.681 | - | Homo sapiens |
| Substance-K receptor GPCR |
Ki | 6.192 | - | Homo sapiens |
| Membrane-associated progesterone receptor component 1 Membrane receptor |
Ki | 7.155 | - | Rattus norvegicus |
| KiSS-1 receptor GPCR |
Ki | 5.44 | - | Homo sapiens |
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Completed suicide | 4171 | 11003.732 | 10010144 |
| Drug abuse | 3179 | 8622.296 | 10013654 |
| Toxicity to various agents | 4237 | 8556.715 | 10070863 |
| Intentional overdose | 1125 | 2259.61 | 10022523 |
| Cardio-respiratory arrest | 1066 | 2132.939 | 10007617 |
| Overdose | 1152 | 1687.782 | 10033295 |
| Suicide attempt | 759 | 1374.402 | 10042464 |
| Alcohol interaction | 306 | 1153.829 | 10001597 |
| Suspected suicide | 324 | 976.259 | 10082458 |
| Intentional product misuse | 621 | 974.407 | 10074903 |
| Alcohol abuse | 265 | 893.304 | 10001584 |
| Alcohol poisoning | 208 | 692.849 | 10001605 |
| Respiratory arrest | 359 | 571.762 | 10038669 |
| Coma | 444 | 536.07 | 10010071 |
| Drug dependence | 311 | 513.41 | 10013663 |
| Exposure to toxic agent | 179 | 495.854 | 10053487 |
| Cardiac arrest | 517 | 472.891 | 10007515 |
| Substance abuse | 187 | 457.571 | 10066169 |
| Alcohol use | 138 | 407.602 | 10048921 |
| Death | 1074 | 403.571 | 10011906 |
| Poisoning deliberate | 176 | 349.144 | 10036000 |
| Drug ineffective | 165 | 347.49 | 10013709 |
| Aggression | 254 | 316.154 | 10001488 |
| Asphyxia | 136 | 283.559 | 10003497 |
| Diarrhoea | 102 | 272.159 | 10012735 |
| Fatigue | 146 | 270.284 | 10016256 |
| Respiratory depression | 174 | 263.457 | 10038678 |
| Poisoning | 161 | 260.37 | 10061355 |
| Pain | 76 | 258.332 | 10033371 |
| Agitation | 287 | 233.159 | 10001497 |
| Arthralgia | 56 | 214.451 | 10003239 |
| Blood alcohol increased | 61 | 210.047 | 10060013 |
| Somnolence | 444 | 198.153 | 10041349 |
| Rash | 75 | 192.654 | 10037844 |
| Mydriasis | 119 | 191.658 | 10028521 |
| Suicidal ideation | 239 | 186.189 | 10042458 |
| Off label use | 197 | 185.956 | 10053762 |
| Fractional exhaled nitric oxide increased | 53 | 181.572 | 10078429 |
| Intentional self-injury | 151 | 180.695 | 10022524 |
| Drug use disorder | 87 | 170.506 | 10079381 |
| Drug withdrawal syndrome | 156 | 167.178 | 10013754 |
| Loss of consciousness | 324 | 166.426 | 10024855 |
| Drug interaction | 550 | 166.006 | 10013710 |
| Pyrexia | 95 | 165.456 | 10037660 |
| Depressed level of consciousness | 226 | 162.007 | 10012373 |
| Substance use disorder | 46 | 161.515 | 10079384 |
| Alcoholism | 65 | 153.378 | 10001639 |
| Pneumonia | 107 | 152.99 | 10035664 |
| Joint swelling | 14 | 147.634 | 10023232 |
| Anaemia | 43 | 140.45 | 10002034 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| BENZETHONIUM CHLORIDE | 40036 | SU | MTHSPL |
| Benzethonium Chloride | 40036 | SU | MTHSPL |
| benzethonium chloride | 40036 | SU | MTHSPL |
| benzethonium chloride | 40036 | PIN | RXNORM |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Benzethonium Chloride used for in pharmaceutical contexts?
Benzethonium Chloride (CAS 121-54-0) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Benzethonium Chloride?
Benzethonium Chloride has 347 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Completed suicide, Drug abuse, Toxicity to various agents, Intentional overdose, Cardio-respiratory arrest. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Benzethonium Chloride also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Benzethonium Chloride with EU status "restricted".
What clinical phase is Benzethonium Chloride in?
Benzethonium Chloride is rendered with ChEMBL max phase 2.
What bioactivity targets are documented for Benzethonium Chloride?
Benzethonium Chloride has 32 bioactivity rows in this page query. Rendered target entries include Alpha-2A adrenergic receptor, Potassium voltage-gated channel subfamily H member 2, Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporter, 5-hydroxytryptamine receptor 2A.