What is the NOAEL for Veratraldehyde?
Veratraldehyde has 15 NOAEL studies in the database. The lowest reported value is 3.2 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Veratraldehyde
Also known as: 3,4-Dimethoxybenzaldehyde, BRN 0473899, EINECS 204-373-2, FEMA No. 3109, Protocatechuecaldehyde dimethyl ether (+5 more)
CAS 120-14-9
Veratraldehyde (CAS 120-14-9) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Veratraldehyde
CAS Number
120-14-9
DTXSID
DTXSID7026285
Molecular Formula
C9H10O3
InChI Key
WJUFSDZVCOTFON-UHFFFAOYSA-N
Monoisotopic Mass
166.062994
Synonyms
3,4-DimethoxybenzaldehydeBRN 0473899EINECS 204-373-2FEMA No. 3109Protocatechuecaldehyde dimethyl etherp-Veratric aldehydeUNII-UI88P68JZDEC No.: 204-373-2204-373-2VERATRUM
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 17.770640315418 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 6.96777958705237 | uM | ACC | - | - | NTP_ICE_endocrine |
| 3.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| UI88P68JZD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UI88P68JZD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UI88P68JZD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UI88P68JZD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 9720 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0572 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =400 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =400 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Veratraldehyde | 204-373-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
3,4-DIMETHOXYBENZALDEHYDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Veratraldehyde?
Veratraldehyde appears on 5 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Veratraldehyde used in cosmetics?
Yes, Veratraldehyde is also indexed as a cosmetic ingredient under the name Veratraldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Veratraldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Veratraldehyde used outside industrial chemicals?
Veratraldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.