What is the NOAEL for Ethyl salicylate?
Ethyl salicylate has 9 NOAEL studies in the database. The lowest reported value is 555U6TZ2MV UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl salicylate
Also known as: 4-10-00-00149, BRN 0907659, EINECS 204-265-5, FEMA No. 2458, Sal ether (+11 more)
CAS 118-61-6
Ethyl salicylate (CAS 118-61-6) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Ethyl salicylate
CAS Number
118-61-6
DTXSID
DTXSID1021958
Molecular Formula
C9H10O3
InChI Key
GYCKQBWUSACYIF-UHFFFAOYSA-N
Monoisotopic Mass
166.062994
Synonyms
4-10-00-00149BRN 0907659EINECS 204-265-5FEMA No. 2458Sal etherSalicyclic acid, ethyl esterSalicylic ethyl esterUNII-555U6TZ2MV2-Hydroxyethylbenzoic acidBenzoic acid, hydroxy-, ethyl esterEthyl hydroxybenzoateEthyl salicyclate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
12 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 555U6TZ2MV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 555U6TZ2MV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 555U6TZ2MV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 555U6TZ2MV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl salicylate | 204-265-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ETHYL SALICYLATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl salicylate?
Ethyl salicylate appears on 5 regulatory/inventory lists including Canada; pharmaceutical, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Ethyl salicylate used in cosmetics?
Yes, Ethyl salicylate is also indexed as a cosmetic ingredient under the name Ethyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl salicylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethyl salicylate used outside industrial chemicals?
Ethyl salicylate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.