What is the NOAEL for N,N-Dimethyldodecan-1-amine?
N,N-Dimethyldodecan-1-amine has 10 NOAEL studies in the database. The lowest reported value is 1 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N-Dimethyldodecan-1-amine
Also known as: Lauryldimethylamine, Armeen DM-12D, Barlene 125, Dimethyl Lauramine, Dimethyl-n-dodecylamine (+2 more)
CAS 112-18-5
N,N-Dimethyldodecan-1-amine (CAS 112-18-5) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N,N-Dimethyldodecan-1-amine is classified GHS Danger (H302, H314, H318, H400, H410, H335, H336, H361) in the chemicals database but is restricted in EU cosmetics at max 2.5%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
10
SOURCE
Chemical inventory jurisdictions
Regulatory lists
11
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
N,N-Dimethyldodecan-1-amine
CAS Number
112-18-5
DTXSID
DTXSID1026906
Molecular Formula
C14H31N
InChI Key
YWFWDNVOPHGWMX-UHFFFAOYSA-N
Monoisotopic Mass
213.24565
Synonyms
LauryldimethylamineArmeen DM-12DBarlene 125Dimethyl LauramineDimethyl-n-dodecylamineEINECS 203-943-8UNII-6V2OM30I1Z
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Anti-static agentSoftener and conditionerCatalyst
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 34.2 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 6V2OM30I1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6V2OM30I1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6V2OM30I1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6V2OM30I1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00699 | fraction | Fu | - | Human | NTP ICE adme parameters |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =50 | mg/kg bw/day | NOAEL | - | Unspecified | EFSA |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecyldimethylamine | 203-943-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
2.5%
Category
Hair Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL109737
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include N,N-Dimethyldodecan-1-amine?
N,N-Dimethyldodecan-1-amine appears on 7 regulatory/inventory lists including detected; Europe; Other indirect contact consumer goods, inert_ingredient; non_food_use; Pesticides, detected; Europe; Vehicle - car interior, and 4 more. Source: EPA CPDat.
Is N,N-Dimethyldodecan-1-amine used in cosmetics?
Yes, N,N-Dimethyldodecan-1-amine is also indexed as a cosmetic ingredient under the name Dimethyl Lauramine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Dimethyldodecan-1-amine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N-Dimethyldodecan-1-amine have different safety status in cosmetics vs industrial chemicals?
N,N-Dimethyldodecan-1-amine is classified GHS Danger (H302, H314, H318, H400, H410, H335, H336, H361) in the chemicals database but is restricted in EU cosmetics at max 2.5%.
Is N,N-Dimethyldodecan-1-amine used outside industrial chemicals?
N,N-Dimethyldodecan-1-amine also appears in cosmetics, pharmaceutical, cannabis databases.