Danger GHS06 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

2-Butoxyethanol

Also known as: Ethylene glycol monobutyl ether, Ethanol, 2-butoxy-, 2-butoxietanol, EGBE, BRN 1732511 (+14 more)

CAS 111-76-2

2-Butoxyethanol (CAS 111-76-2) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H302; H315; H319. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Butoxyethanol →

Cross-Vertical Regulatory Divergence

2-Butoxyethanol is classified GHS Danger (H331, H302, H315, H319) in the chemicals database but is restricted in EU cosmetics at max 4.0%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

2-Butoxyethanol

CAS Number

111-76-2

DTXSID

DTXSID1024097

Molecular Formula

C6H14O2

InChI Key

POAOYUHQDCAZBD-UHFFFAOYSA-N

Monoisotopic Mass

118.09938

Synonyms

Ethylene glycol monobutyl etherEthanol, 2-butoxy-2-butoxietanolEGBEBRN 1732511Caswell No. 121EINECS 203-905-0EPA Pesticide Chemical Code 011501Glycol ether EBUNII-I0P9XEZ9WV2-BUTOXY ETHANOL (ETHYLENE GLYCOL MONOBUTYL ETHER)2-Butossi-etanolo

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	2004	88

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 3; Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2	H331; H302; H315; H319	GHS06	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Flammable liquid and vapour Fatal in contact with skin Harmful if swallowed May cause damage to organs
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the acid-base balance in the body, central nervous system and kidneys. This may result in metabolic acidosis and impaired functions.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood and liver. This may result in impaired functions.
Routes of Exposure	The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 4 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	50 ppm (240 mg/m³)	50	240	Y
NIOSH	TWA	5 ppm (24 mg/m³)	5	24	Y
CAL/OSHA	TWA	20 ppm (97 mg/m³)	20	97	Y
NIOSH	IDLH	700 ppm	700	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventDeodorizerViscosity modifierFragranceFlavouring and nutrientSurfactant (surface active agent)DyePharmaceuticalUV stabilizerDegradant/impurityProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
air; detected; emissions; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected	Elsevier	CPCat
fracking; water	NY Department of Conservation	CPCat
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care; detected; emissions	Elsevier	CPCat
air; detected; emissions; Personal care	Elsevier	CPCat
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Arts and crafts/Office supplies - general arts and crafts supplies; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
=0.05	%	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.25	%	-	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.5	%	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
23	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
23	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
24	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
27	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30	mg/kg bw/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=76	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
82	mg/kg bw/day	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
99	%	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
129	mg/kg bw/d	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
129	mg/kg bw/d	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw/d	-	inhalation	mouse	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw/d	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
222	mg/kg	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
310	mg/kg bw/d	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
370	mg/kg bw/d	-	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
450	mg/kg	-	-	rabbit	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
450	mg/kg bw/d	-	inhalation	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
450	mg/kg bw/d	-	inhalation	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
900	mg/kg bw/d	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg	-	inhalation	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1500	mg/kg bw/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=133	umol-hour/L	BMCL	inhalation	Rat	ToxValDB_IRIS
=39.4	mg/m3	BMCL (05)	inhalation	Rat	ToxValDB_Cal_OEHHA_REL_derivations
=16	mg/m3	BMCL (HEC)	inhalation	Rat	ToxValDB_IRIS
=16	mg/m^3	BMCL (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=133	umol-hour/L	BMDL	oral	Rat	ToxValDB_IRIS
=1.4	mg/kg bw/day	BMDL (HED)	oral	Rat	ToxValDB_IRIS
=1.4	mg/kg/day	BMDL (HED)	oral	-	EPA_IRIS_iris_rfd_systems.csv
4.299	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
6.691	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=98	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
68.7	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
2	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
I0P9XEZ9WV	UNII	FDA UNII substance identifier	-	-	openFDA substances
I0P9XEZ9WV	UNII	FDA UNII substance identifier	-	-	openFDA substances
I0P9XEZ9WV	UNII	FDA UNII substance identifier	-	-	openFDA substances
I0P9XEZ9WV	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.5544	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
0.8332	fraction	Fu	-	Human	NTP_ICE_adme_parameters
1	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-butoxyethanol	203-905-0	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
2-Butoxyethanol (EGBE)	N230 - Certain Glycol Ethers	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

4.0%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BUTOXYETHANOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Butoxyethanol?

2-Butoxyethanol (CAS 111-76-2) is classified under EU CLP Annex VI as Acute Tox. 3; Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2 with signal word Danger. Hazard statements: H331; H302; H315; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Butoxyethanol?

2-Butoxyethanol has 100 NOAEL studies in the database. The lowest reported value is 0.05 %. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include 2-Butoxyethanol?

2-Butoxyethanol appears on 34 regulatory/inventory lists including air; detected; emissions; Europe; Furniture and Furnishings, air; detected; emissions; Europe; Toys and children's products, air; Cons electronics mech appliances and machinery; detected; emissions; Europe, and 31 more. Source: EPA CPDat.

Is 2-Butoxyethanol a carcinogen according to IARC?

2-Butoxyethanol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 2004). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for 2-Butoxyethanol?

Occupational exposure limits for 2-Butoxyethanol are set by OSHA, NIOSH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Butoxyethanol used in cosmetics?

Yes, 2-Butoxyethanol is also indexed as a cosmetic ingredient under the name Butoxyethanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Butoxyethanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Butoxyethanol have different safety status in cosmetics vs industrial chemicals?

2-Butoxyethanol is classified GHS Danger (H331, H302, H315, H319) in the chemicals database but is restricted in EU cosmetics at max 4.0%.

Is 2-Butoxyethanol used outside industrial chemicals?

2-Butoxyethanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.