What is the NOAEL for Adapalene?
Adapalene has 4 NOAEL studies in the database. The lowest reported value is 1L4806J2QF UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Adapalene
Also known as: 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, Differin, Adapaleno, Adapalenum, UNII-1L4806J2QF (+1 more)
CAS 106685-40-9
Adapalene (CAS 106685-40-9) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Adapalene is classified GHS CMR hazard (H302, H315, H317, H319, H335, H361) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Adapalene
CAS Number
106685-40-9
DTXSID
DTXSID5046481
Molecular Formula
C28H28O3
InChI Key
LZCDAPDGXCYOEH-UHFFFAOYSA-N
Monoisotopic Mass
412.203845
Synonyms
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acidDifferinAdapalenoAdapalenumUNII-1L4806J2QFAdapalen
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1L4806J2QF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1L4806J2QF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1L4806J2QF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1L4806J2QF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
adapalene
ChEMBL Phase
Not listed
Adverse Events
257
Bioactivity
5
Frequently Asked Questions
What regulatory lists include Adapalene?
Adapalene appears on 3 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Adapalene used in cosmetics?
Yes, Adapalene is also indexed as a cosmetic ingredient under the name Adapalene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Adapalene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Adapalene have different safety status in cosmetics vs industrial chemicals?
Adapalene is classified GHS CMR hazard (H302, H315, H317, H319, H335, H361) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Is Adapalene used outside industrial chemicals?
Adapalene also appears in cosmetics, pharmaceutical databases.