Cosmetic cross-reference

Adapalene

CAS 106685-40-9

Adapalene (CAS 106685-40-9) is a pharmaceutical compound with 5 bioactivity targets and 257 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral / FAERS

Adverse signals

257

SOURCE IUPHAR / PharmGKB

PubMed IDs

SOURCE DrugCentral 2023 055904D152D6

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Adapalene

CAS Number

106685-40-9

UNII

1L4806J2QF

InChIKey

LZCDAPDGXCYOEH-UHFFFAOYSA-N

ChEMBL ID

CHEMBL1265

DrugCentral Struct ID

Source Match

DrugCentral (CAS), FDA GSRS (UNII)

Synonyms and normalized names

Differin

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE ChEMBL 36 activities + assays 5 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
Glycine receptor subunit alpha-1 Ion channel	EC50	5.89	-	Homo sapiens
Retinoic acid receptor alpha Nuclear hormone receptor	Ki	5.96	-	Homo sapiens
Retinoic acid receptor beta Nuclear hormone receptor	Ki	7.47	-	Homo sapiens
Retinoic acid receptor gamma Nuclear hormone receptor	Ki	6.89	-	Homo sapiens
Aspartate aminotransferase, cytoplasmic Enzyme	IC50	4.66	-	Homo sapiens

SOURCE DrugCentral 2023 / FAERS disproportionality 26 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Skin burning sensation	224	1081.793	10054786
Erythema	300	731.458	10015150
Dry skin	205	645.199	10013786
Skin exfoliation	159	496.436	10040844
Skin irritation	102	423.581	10040880
Pain of skin	91	353.653	10033474
Chemical burn of skin	25	180.648	10057941
Inappropriate schedule of product administration	93	152.149	10081572
Skin swelling	33	136.811	10053262
Pruritus	113	103.728	10037087
Acne	42	102.917	10000496
Swelling face	53	97.193	10042682
Overdose	66	76.972	10033295
Dermatitis	30	71.348	10012431
Rash macular	31	66.596	10037867
Urticaria	61	64.854	10046735
Rash papular	27	62.891	10037876
Hypersensitivity	73	59.672	10020751
Acne cystic	12	55.106	10000503
Rash	105	54.326	10037844
Sensitive skin	13	50.6	10081765
Skin hyperpigmentation	17	48.741	10040865
Eye swelling	24	47.032	10015967
Underdose	27	46.102	10057362
Skin fissures	19	45.64	10040849
Rash erythematous	28	40.762	10037855

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE IUPHAR ligand-target interactions 3 interactions

IUPHAR Ligand-Target Data

Curated ligand-target interaction rows with action, affinity, and literature identifiers.

Target	Action	Affinity	PubMed
Retinoic acid receptor-β RARB	Agonist	7.46999979019165 pKi	8544175
Retinoic acid receptor-γ RARG	Agonist	6.889999866485596 pKi	8544175
Retinoic acid receptor-α RARA	Agonist	5.960000038146973 pKi	8544175

SOURCE RxNorm drug names 4 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
ADAPALENE	60223	SU	MTHSPL
Adapalene	60223	SU	MTHSPL
adapalene	60223	IN	RXNORM
Differin	153184	BN	RXNORM

SOURCE SIDER side-effect resource 80 side-effect rows

Side Effects

SIDER side-effect terms mapped to the drug or same-CAS compound identity.

Side Effect	Drug Name	MedDRA Type	Concept ID
Abrasion NOS	adapalene	LLT	C1302752
Angioedema	adapalene	LLT	C0002994
Angioedema	adapalene	PT	C0002994
Application site pain	adapalene	LLT	C0521491
Application site pain	adapalene	PT	C0521491
Burning sensation	adapalene	LLT	C0085624
Burning sensation	adapalene	PT	C0085624
Conjunctivitis	adapalene	LLT	C0009763
Conjunctivitis	adapalene	PT	C0009763
Convulsion	adapalene	LLT	C0036572
Convulsion	adapalene	PT	C0036572
Dermatitis	adapalene	LLT	C0011603
Dermatitis	adapalene	PT	C0011603
Dermatitis	adapalene	PT	C0011603
Dermatitis atopic	adapalene	LLT	C0011615
Dermatitis atopic	adapalene	PT	C0011615
Dermatitis bullous	adapalene	PT	C0085932
Dermatitis contact	adapalene	LLT	C0011616
Dermatitis contact	adapalene	PT	C0011616
Dermatitis contact	adapalene	PT	C0011616
Dermatitis exfoliative	adapalene	LLT	C0011606
Dermatitis exfoliative	adapalene	PT	C0011606
Dermatitis irritant contact	adapalene	LLT	C0162823
Drug ineffective	adapalene	PT	C0852908
Dry skin	adapalene	LLT	C0151908
Dry skin	adapalene	PT	C0151908
Eczema	adapalene	LLT	C0013595
Eczema	adapalene	PT	C0013595
Erythema	adapalene	LLT	C0041834
Erythema	adapalene	PT	C0041834
Erythema	adapalene	PT	C0041834
Erythema of eyelid	adapalene	LLT	C0239454
Erythema of eyelid	adapalene	PT	C0239454
Excoriation	adapalene	PT	C0015256
Eye pain	adapalene	LLT	C0151827
Eye pain	adapalene	PT	C0151827
Eyelid irritation	adapalene	LLT	C1112366
Eyelid irritation	adapalene	PT	C1112366
Eyelid oedema	adapalene	LLT	C0162285
Eyelid oedema	adapalene	PT	C0162285
Eyelid oedema	adapalene	PT	C0162285
Eyelids pruritus	adapalene	LLT	C0849918
Eyelids pruritus	adapalene	PT	C0849918
Face oedema	adapalene	LLT	C0542571
Face oedema	adapalene	PT	C0542571
Feeling hot	adapalene	PT	C2939147
Foetal disorder	adapalene	LLT	C0015929
Foetal disorder	adapalene	PT	C0015929
Hepatitis	adapalene	LLT	C0019158
Hepatitis	adapalene	PT	C0019158
Herpes labialis	adapalene	LLT	C0019345
Herpes simplex	adapalene	LLT	C0019348
Herpes simplex	adapalene	PT	C0019348
Hypersensitivity	adapalene	LLT	C0020517
Hypersensitivity	adapalene	PT	C0020517
Instillation site pain	adapalene	PT	C0858797
Keratitis	adapalene	PT	C0022568
Keratoconjunctivitis	adapalene	LLT	C0022573
Lack of drug effect	adapalene	LLT	C0151810
Lip swelling	adapalene	LLT	C0240211
Lip swelling	adapalene	PT	C0240211
Optic neuritis	adapalene	PT	C0029134
Oral herpes	adapalene	PT	C0341012
Pain	adapalene	LLT	C0030193
Pain	adapalene	PT	C0030193
Pain	adapalene	PT	C0030193
Pain of skin	adapalene	LLT	C0241136
Pain of skin	adapalene	PT	C0241136
Papilloedema	adapalene	LLT	C0030353
Papilloedema	adapalene	PT	C0030353
Photosensitivity reaction	adapalene	PT	C0162830
Photosensitivity reaction	adapalene	PT	C0162830
Phototoxicity	adapalene	LLT	C1527358
Pruritus	adapalene	LLT	C0033774
Pruritus	adapalene	PT	C0033774
Rash	adapalene	LLT	C0015230
Rash	adapalene	PT	C0015230
Rash pustular	adapalene	PT	C0085641
Rash vesicular	adapalene	LLT	C0221203
Rash vesicular	adapalene	PT	C0221203

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Adapalene used for in pharmaceutical contexts?

Adapalene (CAS 106685-40-9) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Adapalene?

Adapalene has 257 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Skin burning sensation, Erythema, Dry skin, Skin exfoliation, Skin irritation. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Adapalene also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for Adapalene with EU status "restricted".

What clinical phase is Adapalene in?

No phase 1-4 clinical development badge is rendered for Adapalene because the matched compound identifier rows do not contain a max-phase value.

What bioactivity targets are documented for Adapalene?

Adapalene has 5 bioactivity rows in this page query. Rendered target entries include Glycine receptor subunit alpha-1, Retinoic acid receptor alpha, Retinoic acid receptor beta, Retinoic acid receptor gamma, Aspartate aminotransferase, cytoplasmic.