Danger GHS02GHS04GHS08 NOAEL Data IARC Group 1 Prop 65 REACH Registered Cosmetic Ingredient

1,3-Butadiene

Also known as: 1,3 Butadieno, Buta-1,3-dien, Butadiene-1,3, Vinylethylene, Erythrene (+10 more)

CAS 106-99-0

1,3-Butadiene (CAS 106-99-0) is a chemical substance with GHS signal word Danger; key hazard signal: H220; H350; H340. Key regulatory status: California Proposition 65, REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Butadiene →

SOURCE noael studies public
NOAEL studies
52
SOURCE chemical inventory jurisdictions
Regulatory lists
13
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
1,3-Butadiene
CAS Number
106-99-0
DTXSID
DTXSID3020203
Molecular Formula
C4H6
InChI Key
KAKZBPTYRLMSJV-UHFFFAOYSA-N
Monoisotopic Mass
54.04695
Synonyms
1,3 ButadienoButa-1,3-dienButadiene-1,3VinylethyleneErythreneButadiene monomerButadiene-1,3-uninhibitedEINECS 203-450-8NCI-C50602Buta-1,3-dieenButadieenButadien

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 1Carcinogenic to humans2009Sup 7, 54, 71, 97, 100F

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 2 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-
-developmental, female, maleNoYes-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Gas 1; Press. Gas; Carc. 1A; Muta. 1BH220; H350; H340GHS02; GHS04; GHS08Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsContains gas under pressure; may explode if heated Extremely flammable gas May cause cancer May cause genetic defects
Short-term EffectsThe substance at very high concentrations is irritating to the eyes and respiratory tract. Rapid evaporation of the liquid may cause frostbite. Inhalation of high concentrations may cause depression of the central nervous system.
Long-term EffectsThe substance may have effects on the bone marrow. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells.
Routes of ExposureThe substance can be absorbed into the body by inhalation.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 8 records
AgencyMetricValueppmmg/m3Skin
OSHATWA1 ppm (2.21 mg/m³)12.21N
OSHASTEL5 ppm (11 mg/m³)511N
CAL/OSHATWA1 ppm (2.2 mg/m³)12.2-
CAL/OSHASTEL5 ppm (11 mg/m³)511-
NIOSHIDLH2000 ppm2000--
AIHAERPG-110 ppm10--
AIHAERPG-2500 ppm500--
AIHAERPG-35000 ppm5000--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records
MonomersNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 13 records
ListKeywordSource
CEDIFDAUnited States Food and Drug Administration (FDA)
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
detected; drinking_water; MN Chemical ScreeningEPAState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPAState of Minnesota
childrenMaine Department of Environmental ProtectionState of Maine
Europe; Food contact items; Toys and children's productsDanish EPADanish EPA
Europe; Food contact items; Toys and children's productsDanish EPADanish EPA
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
banned; Europe; Personal careEuropean CommissionCosIng
Cons electronics mech appliances and machinery; EuropeDanish Environmental Protection AgencyDanish EPA
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Europe; Road vehiclesDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 52 studies
ValueUnitEndpointRouteSpeciesSource
=3.09731mg/m3BMC (05)inhalationMouseToxValDB_Cal_OEHHA_REL_derivations
=2.21236mg/m3BMC (10)inhalationMouseToxValDB_IRIS
=2.23449mg/m3BMCL (05)inhalationMouseToxValDB_Cal_OEHHA_REL_derivations
=39.1588mg/m3BMCL (05)inhalationMouseToxValDB_Cal_OEHHA_REL_derivations
=1.94688mg/m3BMCL (10 HEC)inhalationMouseToxValDB_IRIS
=1.98mg/m3BMCL (10 HEC)inhalationMouseToxValDB_IRIS
=113.494mg/m3BMCL (1SD)inhalationMouseToxValDB_TX_TCEQ
=1.98mg/m^3BMCL 10 (HEC)inhalation-EPA_IRIS_iris_rfc_systems.csv
SQE0.4ug/dayCalifornia Proposition 65 NSRL--California Proposition 65
SQE0.4ug/dayCalifornia Proposition 65 NSRL--California Proposition 65
SQE0.4ug/dayCalifornia Proposition 65 NSRL--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmental, female, malelisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmental, female, malelisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmental, female, malelisting typeCalifornia Proposition 65 listing--California Proposition 65
23.89uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
37.19uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
JSD5FGP5VDUNIIFDA UNII substance identifier--openFDA substances
JSD5FGP5VDUNIIFDA UNII substance identifier--openFDA substances
JSD5FGP5VDUNIIFDA UNII substance identifier--openFDA substances
JSD5FGP5VDUNIIFDA UNII substance identifier--openFDA substances
0.3548fractionFu-RatNTP_ICE_adme_parameters
0.5027fractionFu-HumanNTP_ICE_adme_parameters
1IARC groupIARC carcinogenicity classification--IARC Monographs
1IARC groupIARC carcinogenicity classification--IARC Monographs
1IARC groupIARC carcinogenicity classification--IARC Monographs
1unitlessIARC group--NTP_ICE_cancer
0.00003ug/m3Inhalation risk unitInhalation-NTP_ICE_cancer
283.0049mg/LLC50Inhalation-NTP_ICE_acute_inhalation
285mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=5480mg/kg bwLD50oralRatNTP_ICE_acute_oral
=2.21236mg/m3LELinhalationRatToxValDB_EPA_TSCA_8e
=11.0618mg/m3LELinhalationMouse, RatToxValDB_EPA_TSCA_8e
=65ppmLELoralMouseToxValDB_EPA_TSCA_8e
=44247.3mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=3318.54mg/m3LOAELinhalationRatToxValDB_HPVIS
=5530.91mg/m3LOAELinhalationMouseToxValDB_HPVIS
>17679mg/m3LOAELinhalationRatToxValDB_HPVIS
=17698.9mg/m3LOAELinhalationRatToxValDB_HPVIS
=200ppmLOEL--INCHEM_WHO_cicads_cicads_cicad30
=2212.36mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=88.4945mg/m3NOAELinhalationMouseToxValDB_HPVIS
=442.473mg/m3NOAELinhalationMouseToxValDB_HPVIS
=663.709mg/m3NOAELinhalationRatToxValDB_HPVIS
=2212.36mg/m3NOAELinhalationRatToxValDB_HPVIS
=2765.45mg/m3NOAELinhalationMouseToxValDB_HPVIS
=13274.2mg/m3NOAELinhalationRatToxValDB_HPVIS
=0.002mg/m3RfCinhalationHumanToxValDB_IRIS

Showing 50 of 52 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredButa-1,3-diene203-450-8ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
1,3-Butadiene--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BUTADIENE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,3-Butadiene?

1,3-Butadiene (CAS 106-99-0) is classified under EU CLP Annex VI as Flam. Gas 1; Press. Gas; Carc. 1A; Muta. 1B with signal word Danger. Hazard statements: H220; H350; H340. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,3-Butadiene?

1,3-Butadiene has 52 NOAEL studies in the database. The lowest reported value is 0.00003 ug/m3 via Inhalation. Source: NTP_ICE_cancer.

What regulatory lists include 1,3-Butadiene?

1,3-Butadiene appears on 11 regulatory/inventory lists including CEDI, OEHHA Proposition 65 (3/2019), detected; drinking_water; MN Chemical Screening, and 8 more. Source: EPA CPDat.

Is 1,3-Butadiene a carcinogen according to IARC?

1,3-Butadiene is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 1,3-Butadiene on the California Proposition 65 list?

Yes, 1,3-Butadiene is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for 1,3-Butadiene?

Occupational exposure limits for 1,3-Butadiene are set by OSHA, CAL/OSHA, NIOSH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1,3-Butadiene used in cosmetics?

Yes, 1,3-Butadiene is also indexed as a cosmetic ingredient under the name Butadiene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3-Butadiene come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,3-Butadiene have different safety status in cosmetics vs industrial chemicals?

1,3-Butadiene is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H350, H340).

Is 1,3-Butadiene used outside industrial chemicals?

1,3-Butadiene also appears in cosmetics, pharmaceutical, cannabis databases.