What is the NOAEL for (4-Methoxyphenyl)methanol?
(4-Methoxyphenyl)methanol has 19 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(4-Methoxyphenyl)methanol
Also known as: 4-Methoxy benzenemethanol, Anise alcohol, p-Anisyl alcohol, 4-06-00-05909, Anisalcohol, p- (+5 more)
CAS 105-13-5
(4-Methoxyphenyl)methanol (CAS 105-13-5) is a chemical substance. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
(4-Methoxyphenyl)methanol is classified GHS Danger (H302, H317, H318) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
15
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
16 fields
Name
(4-Methoxyphenyl)methanol
CAS Number
105-13-5
DTXSID
DTXSID6044357
Molecular Formula
C8H10O2
InChI Key
MSHFRERJPWKJFX-UHFFFAOYSA-N
Monoisotopic Mass
138.06808
Synonyms
4-Methoxy benzenemethanolAnise alcoholp-Anisyl alcohol4-06-00-05909Anisalcohol, p-p-Anisol alcoholBRN 0636654EINECS 203-273-6FEMA No. 2099UNII-7N6XGV3U49
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceNo specific technical functionDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| children; Europe; nondetect; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; Europe; nondetect; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 822.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >1000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 90.03 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =2.468 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =4.93 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 7N6XGV3U49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7N6XGV3U49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7N6XGV3U49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7N6XGV3U49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.9392 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 1.23 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =20 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-methoxybenzyl alcohol | 203-273-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL294431
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (4-Methoxyphenyl)methanol?
(4-Methoxyphenyl)methanol appears on 13 regulatory/inventory lists including Europe, Europe; Personal care; restricted, children; Europe; nondetect; Personal care, and 10 more. Source: EPA CPDat.
Is (4-Methoxyphenyl)methanol used in cosmetics?
Yes, (4-Methoxyphenyl)methanol is also indexed as a cosmetic ingredient under the name Anise Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (4-Methoxyphenyl)methanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does (4-Methoxyphenyl)methanol have different safety status in cosmetics vs industrial chemicals?
(4-Methoxyphenyl)methanol is classified GHS Danger (H302, H317, H318) in the chemicals database but is restricted in EU cosmetics.
Is (4-Methoxyphenyl)methanol used outside industrial chemicals?
(4-Methoxyphenyl)methanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.