What is the NOAEL for Acetaminophen?
Acetaminophen has 65 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Acetaminophen
Also known as: 4-Acetamidophenol, Paracetamol, 4-hydroxyacetanilide, APAP, 4-13-00-01091 (+15 more)
CAS 103-90-2
Acetaminophen (CAS 103-90-2) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 27 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
65
SOURCE
chemical inventory jurisdictions
Regulatory lists
27
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Acetaminophen
CAS Number
103-90-2
DTXSID
DTXSID2020006
Molecular Formula
C8H9NO2
InChI Key
RZVAJINKPMORJF-UHFFFAOYSA-N
Monoisotopic Mass
151.063329
Synonyms
4-AcetamidophenolParacetamol4-hydroxyacetanilideAPAP4-13-00-01091Acetamide, N-(p-hydroxyphenyl)-p-AcetaminophenolEINECS 203-157-5NCI-C55801Pyregesic-CApitrelalChildren's Acetaminophen Elixir Solution
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 50, 73 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | May cause damage to liver and kidneys through prolonged or repeated exposure if swallowed Toxic to aquatic life |
| Long-term Effects | Ingestion may cause effects on the kidneys and liver. This may result in impaired functions. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
54 records
PharmaceuticalSoftener and conditionerStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
27 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| detected; pharmaceutical; wastewater | USGS | United States Geological Survey (USGS) |
| detected; pharmaceutical; soil | USGS | United States Geological Survey (USGS) |
| detected; pharmaceutical; wastewater | Drinking Water Inspectorate | CPCat |
| detected; pharmaceutical; wastewater | Drinking Water Inspectorate | CPCat |
| detected; MN Chemical Screening; surface_water | National Parks Service | State of Minnesota |
| detected; ground_water; MN Chemical Screening; pharmaceutical | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | NPS & EPA | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| detected; Europe; surface_water; wastewater | Drinking Water Inspectorate | CPCat |
| Europe; pharmaceutical | Danish Environmental Protection Agency | Danish EPA |
| children; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; pharmaceutical | Drinking Water Inspectorate | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 65 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.3598 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 15.83 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =12.006 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 362O9ITL9D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 362O9ITL9D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 362O9ITL9D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 362O9ITL9D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.82 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 0.9398 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =1944 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =30 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =30 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =35 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =35 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =40 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =40 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =90 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =90 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =110 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =110 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =625 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =625 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =930 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =930 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =46.8 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =111 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >320 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| >320 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =625 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =625 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1000 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1000 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >1200 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ToxRefDB |
| >1200 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1875 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1875 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =300 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =1400 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =4925 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =12500 | ppm | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =310 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =310 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =480 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB_ToxRefDB |
Showing 50 of 65 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Paracetamol | 203-157-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACETAMINOPHEN
ChEMBL Phase
4
Adverse Events
27587
Bioactivity
27
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acetaminophen?
Acetaminophen appears on 11 regulatory/inventory lists including pharmaceutical, detected; pharmaceutical; wastewater, detected; pharmaceutical; soil, and 8 more. Source: EPA CPDat.
Is Acetaminophen a carcinogen according to IARC?
Acetaminophen is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Acetaminophen used in cosmetics?
Yes, Acetaminophen is also indexed as a cosmetic ingredient under the name Acetaminophen. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetaminophen come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Acetaminophen used outside industrial chemicals?
Acetaminophen also appears in cosmetics, pharmaceutical, cannabis databases.