NOAEL Data REACH Registered Cosmetic Ingredient

2,2'-(Octadecylimino)diethanol

Also known as: Stearyldiethanolamine, Ethanol, 2,2'-(octadecylimino)bis-, Ethanol, 2,2'-(octadecylimino)di-, 2,2'-(Octadecylimino)bis[ethanol], Amiet 302 (+15 more)

CAS 10213-78-2

2,2'-(Octadecylimino)diethanol (CAS 10213-78-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for PEG-2 Stearamine →

Cross-Vertical Regulatory Divergence

2,2'-(Octadecylimino)diethanol is classified GHS Danger (H302, H315, H318, H319, H400, H410, H412) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

2,2'-(Octadecylimino)diethanol

CAS Number

10213-78-2

DTXSID

DTXSID3036311

Molecular Formula

C22H47NO2

InChI Key

NDLNTMNRNCENRZ-UHFFFAOYSA-N

Monoisotopic Mass

357.36068

Synonyms

StearyldiethanolamineEthanol, 2,2'-(octadecylimino)bis-Ethanol, 2,2'-(octadecylimino)di-2,2'-(Octadecylimino)bis[ethanol]Amiet 302Anstex SA 20Stearylbis(hydroxyethyl)amineOctadecyldiethanolamineOctadecylbis(2-hydroxyethyl)amineN-StearyldiethanolamineN,N-DiethanolstearylamineN,N-Bis-β-hydroxyethyl-N-octadecylamine

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

Anti-static agentEmulsifierDispersing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
CEDI	FDA	United States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
=2.11	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
7J75C7GK1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
7J75C7GK1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
7J75C7GK1M	UNII	FDA UNII substance identifier	-	-	openFDA substances
=30	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2,2'-(octadecylimino)bisethanol	233-520-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2,2'-(Octadecylimino)diethanol?

2,2'-(Octadecylimino)diethanol has 5 NOAEL studies in the database. The lowest reported value is 2.11 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2,2'-(Octadecylimino)diethanol?

2,2'-(Octadecylimino)diethanol appears on 3 regulatory/inventory lists including CEDI, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018). Source: EPA CPDat.

Is 2,2'-(Octadecylimino)diethanol used in cosmetics?

Yes, 2,2'-(Octadecylimino)diethanol is also indexed as a cosmetic ingredient under the name PEG-2 Stearamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2'-(Octadecylimino)diethanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,2'-(Octadecylimino)diethanol have different safety status in cosmetics vs industrial chemicals?

2,2'-(Octadecylimino)diethanol is classified GHS Danger (H302, H315, H318, H319, H400, H410, H412) in the chemicals database but is allowed in EU cosmetics.

Is 2,2'-(Octadecylimino)diethanol used outside industrial chemicals?

2,2'-(Octadecylimino)diethanol also appears in cosmetics, cannabis databases.