Cosmetic cross-reference

Propylene Glycol

CAS 57-55-6

Propylene Glycol (CAS 57-55-6) is a Phase 3 pharmaceutical compound with 3 bioactivity targets and 67 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral

Adverse signals

SOURCE IUPHAR/BPS

PubMed IDs

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Propylene Glycol

CAS Number

57-55-6

UNII

6DC9Q167V3

InChIKey

DNIAPMSPPWPWGF-UHFFFAOYSA-N

ChEMBL ID

CHEMBL286398

Molecule Type

Small molecule

Source Match

EMBL-EBI ChEMBL (INCHIKEY)

natural product

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Clinical Development Phase

Highest clinical development phase rendered from the matched compound identifier rows.

Phase 3

Late-stage clinical development phase from the compound identifier source.

ChEMBL CHEMBL286398 | Small molecule

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE EMBL-EBI ChEMBL 3 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
-	AC50	30000 nM	32	-
-	Potency	19647.583333333332 nM	6	-
-	IC50	19976.309999999998 nM	1	-

SOURCE DrugCentral 67 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Eye irritation	71	194.28	10015946
Appendicolith	44	152.44	10074458
Appendicitis	44	109.109	10003011
Blood phosphorus increased	33	96.872	10050196
Ventricular fibrillation	44	92.615	10047290
Foreign body sensation in eyes	23	88.428	10051116
Myasthenia gravis	31	86.995	10028417
Cardiogenic shock	45	85.251	10007625
Ocular hyperaemia	42	84.718	10030041
Ocular procedural complication	16	80.486	10080964
Eye pain	45	79.435	10015958
Blood uric acid increased	30	75.323	10005861
Instillation site pain	15	66.806	10022459
Eye discharge	23	65.786	10015915
Ascites	48	62.596	10003445
Stress	48	59.473	10042209
Keratitis	19	59.099	10023332
Chronic obstructive pulmonary disease	48	55.051	10009033
Pneumonia viral	22	54.9	10035737
Erythema of eyelid	16	54.267	10015237
Multiple organ dysfunction syndrome	51	51.686	10077361
Breath sounds abnormal	23	49.007	10064780
Eye pruritus	26	48.49	10052140
Dry eye	33	48.484	10013774
Vision blurred	48	44.729	10047513
Dry mouth	43	44.364	10013781
Abdominal distension	47	41.574	10000060
Cardiac murmur	22	40.963	10007586
Visual acuity reduced	26	39.888	10047531
Hyperphosphataemia	15	39.149	10020711
Corneal epithelium defect	9	37.873	10011010
Drug therapy	9	33.832	10063370
Hyponatraemia	49	33.375	10021036
Iron deficiency	16	32.763	10022970
Presyncope	25	30.931	10036653
Analgesic therapy	8	30.587	10053469
Corneal disorder	10	30.494	10061453
Sleep disorder therapy	8	30.423	10040990
Sepsis	62	29.088	10040047
Nasal congestion	31	28.898	10028735
Eyelids pruritus	8	28.565	10051627
Eyelid irritation	7	28.452	10057385
Incorrect route of product administration	23	28.433	10081202
Corneal opacity	8	27.95	10011035
Eosinophilia	23	27.501	10014950
Hypophosphataemia	17	26.916	10021058
Scleral hyperaemia	6	26.269	10059096
Neuralgia	21	26.241	10029223
Constipation	63	26.157	10010774
Ulcerative keratitis	10	25.947	10064996

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE NLM RxNorm 5 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
PROPYLENE GLYCOL	34693	SU	MTHSPL
Propylene Glycol	34693	SU	MTHSPL
Propylene glycol	34693	SU	MTHSPL
propylene glycol	34693	SU	MTHSPL
propylene glycol	34693	IN	RXNORM

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Propylene Glycol used for in pharmaceutical contexts?

Propylene Glycol (CAS 57-55-6) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Propylene Glycol?

Propylene Glycol has 67 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Eye irritation, Appendicolith, Appendicitis, Blood phosphorus increased, Ventricular fibrillation. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Propylene Glycol also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for Propylene Glycol with EU status "permitted".

What clinical phase is Propylene Glycol in?

Propylene Glycol is rendered with ChEMBL max phase 3.