Cosmetic cross-reference

Glutamic Acid

CAS 56-86-0

Glutamic Acid (CAS 56-86-0) is a Phase 3 pharmaceutical compound with 27 bioactivity targets and 2 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral

Adverse signals

SOURCE IUPHAR/BPS

PubMed IDs

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Glutamic Acid

CAS Number

56-86-0

UNII

3KX376GY7L

InChIKey

WHUUTDBJXJRKMK-VKHMYHEASA-N

ChEMBL ID

CHEMBL575060

Molecule Type

Small molecule

Source Match

EMBL-EBI ChEMBL (INCHIKEY)

Synonyms and normalized names

glutamate

natural product

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Clinical Development Phase

Highest clinical development phase rendered from the matched compound identifier rows.

Phase 3

Late-stage clinical development phase from the compound identifier source.

ChEMBL CHEMBL575060 | Small molecule

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE EMBL-EBI ChEMBL 48 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
-	EC50	19779.175698324023 nM	156	-
-	Ki	5053.974411764706 nM	92	-
-	IC50	10193.532063492064 nM	54	-
-	AC50	30158.23741935484 nM	32	-
-	Potency	13790.855555555556 nM	8	-
Adenosine receptor A3 GPCR	IC50	6.21	-	Homo sapiens
Glutathione reductase, mitochondrial Enzyme	Ki	4.37	-	Homo sapiens
Glutamate receptor 1 Ion channel	Ki	5.87	-	Homo sapiens
Glutamate receptor ionotropic, kainate 1 Ion channel	Ki	6.15	-	Homo sapiens
Glutamate receptor 2 Ion channel	Ki	6.03	-	Homo sapiens
Metabotropic glutamate receptor 1 GPCR	Ki	6.6	-	Homo sapiens
Glutamate dehydrogenase 1, mitochondrial Enzyme	-	-	-	Homo sapiens
Glutamate dehydrogenase 2, mitochondrial Enzyme	-	-	-	Homo sapiens
Glutamate receptor ionotropic, kainate 5 Ion channel	Ki	6.15	-	Homo sapiens
Metabotropic glutamate receptor 5 GPCR	Ki	6.41	-	Homo sapiens
Metabotropic glutamate receptor 4 GPCR	Ki	5.85	-	Homo sapiens
Glutamate receptor 4 Ion channel	Ki	6.06	-	Homo sapiens
Glutamate receptor ionotropic, kainate 2 Ion channel	Ki	5.96	-	Homo sapiens
Glutamate receptor ionotropic, kainate 3 Ion channel	Ki	6.1	-	Homo sapiens
Metabotropic glutamate receptor 7 GPCR	EC50	5.93	-	Homo sapiens
Metabotropic glutamate receptor 6 GPCR	EC50	5.31	-	Homo sapiens
Metabotropic glutamate receptor 2 GPCR	EC50	6.54	-	Homo sapiens
Excitatory amino acid transporter 1 Transporter	Ki	4.46	-	Homo sapiens
Excitatory amino acid transporter 2 Transporter	Ki	4.21	-	Homo sapiens
Excitatory amino acid transporter 3 Transporter	Ki	7.29	-	Homo sapiens
Glutamate receptor 2 Ion channel	Ki	6.55	-	Rattus norvegicus
Glutamate receptor 3 Ion channel	Ki	6.595	-	Homo sapiens
Glutamate receptor ionotropic, kainate 4 Ion channel	Ki	7.738	-	Homo sapiens
Metabotropic glutamate receptor 3 GPCR	Ki	7.4	-	Homo sapiens
Metabotropic glutamate receptor 8 GPCR	IC50	5.7	-	Homo sapiens
Glutamate receptor ionotropic, NMDA 1 Ion channel	EC50	5.54	-	Rattus norvegicus
Glutamate receptor ionotropic, kainate 2 Ion channel	Ki	5.48	-	Rattus norvegicus
Glutamate receptor ionotropic, kainate 1 Ion channel	Ki	6.85	-	Rattus norvegicus
Metabotropic glutamate receptor 4 GPCR	EC50	4.92	-	Rattus norvegicus
Metabotropic glutamate receptor 6 GPCR	EC50	4.8	-	Rattus norvegicus
Glutamate receptor 1 Ion channel	EC50	4.46	-	Rattus norvegicus
Glutamate receptor 3 Ion channel	EC50	4	-	Rattus norvegicus
Glutamate receptor 4 Ion channel	EC50	4.77	-	Rattus norvegicus
Glutamate receptor ionotropic, kainate 3 Ion channel	Ki	6.31	-	Rattus norvegicus
Glutamate racemase Enzyme	Ki	4.55	-	Lactobacillus fermentum
Metabotropic glutamate receptor 8 GPCR	Ki	5.47	-	Rattus norvegicus
Metabotropic glutamate receptor 8 GPCR	EC50	7.66	-	Mus musculus
Metabotropic glutamate receptor 5 GPCR	EC50	5.36	-	Rattus norvegicus
Metabotropic glutamate receptor 1 GPCR	EC50	5	-	Rattus norvegicus
Metabotropic glutamate receptor 2 GPCR	EC50	5.4	-	Rattus norvegicus
Metabotropic glutamate receptor 3 GPCR	EC50	5.52	-	Rattus norvegicus
Glutamate racemase Enzyme	Ki	5.24	-	Helicobacter pylori (strain ATCC 700392 / 26695)
Excitatory amino acid transporter 4 Transporter	IC50	4.89	-	Rattus norvegicus

SOURCE DrugCentral 2 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Toxic epidermal necrolysis	21	76.155	10044223
Foetal growth restriction	15	66.301	10070531

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE IUPHAR/BPS 19 interactions

IUPHAR Ligand-Target Data

Curated ligand-target interaction rows with action, affinity, and literature identifiers.

Target	Action	Affinity	PubMed
mGlu 1 receptor GRM1	Agonist	4.800000190734863 pEC50	10443583
mGlu 1 receptor Grm1	Full agonist	6.4 pKi	12695537\|11080213
mGlu 2 receptor GRM2	Agonist	4.699999809265137 pEC50	10443583
mGlu 2 receptor Grm2	Full agonist	5.4 pKi	8022410\|10652549
mGlu 2 receptor GRM2	Full agonist	4.9 pKi	10530814
mGlu 3 receptor GRM3	Agonist	5.300000190734863 pEC50	10443583
mGlu 3 receptor GRM3	Full agonist	7.4 pKi	10530814
mGlu 3 receptor Grm3	Full agonist	6.4 pKi	10884552
mGlu 4 receptor GRM4	Agonist	4.699999809265137 pEC50	10443583
mGlu 4 receptor Grm4	Full agonist	4.9 pKi	9144638\|10187777\|1361913\|9357538
mGlu 5 receptor GRM5	Agonist	5.0 pEC50	10443583
mGlu 5 receptor Grm5	Full agonist	6.1 pIC50	11080213
mGlu 6 receptor GRM6	Agonist	4.800000190734863 pEC50	10443583
mGlu 6 receptor Grm6	Full agonist	4.4 pEC50	9833633
mGlu 6 receptor GRM6	Full agonist	5.2 pEC50	9144651
mGlu 7 receptor GRM7	Agonist	3.0 pEC50	10443583
mGlu 7 receptor GRM7	Full agonist	3.1 pKi	11138847
mGlu 8 receptor GRM8	Agonist	4.900000095367432 pEC50	10443583
mGlu 8 receptor GRM8	Full agonist	5.0 pIC50	9473604\|10216218

SOURCE NLM RxNorm 5 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
glutamic acid	25916	SU	MTHSPL
Glutamic Acid	25916	SU	MTHSPL
GLUTAMIC ACID	25916	SU	MTHSPL
glutamic acid	25916	PIN	RXNORM
glutamate	70602	IN	RXNORM

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Glutamic Acid used for in pharmaceutical contexts?

Glutamic Acid (CAS 56-86-0) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Glutamic Acid?

Glutamic Acid has 2 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Toxic epidermal necrolysis, Foetal growth restriction. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Glutamic Acid also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for L-Glutamic Acid with EU status "permitted".

What clinical phase is Glutamic Acid in?

Glutamic Acid is rendered with ChEMBL max phase 3.

What bioactivity targets are documented for Glutamic Acid?

Glutamic Acid has 48 bioactivity rows in this page query. Rendered target entries include Adenosine receptor A3, Glutathione reductase, mitochondrial, Glutamate receptor 1, Glutamate receptor ionotropic, kainate 1, Glutamate receptor 2.