Sunitinib

CAS 557795-19-4

Sunitinib (CAS 557795-19-4) is a pharmaceutical compound with 80 bioactivity targets and 498 adverse event associations.

SOURCE NLM DailyMed
Label records
0
SOURCE EMBL-EBI ChEMBL
Bioactivity
283
SOURCE DrugCentral
Adverse signals
498
SOURCE IUPHAR/BPS
PubMed IDs
25
SOURCE DrugCentral 055904D152D6

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name
Sunitinib
CAS Number
557795-19-4
UNII
V99T50803M
InChIKey
WINHZLLDWRZWRT-ATVHPVEESA-N
ChEMBL ID
CHEMBL1567
DrugCentral Struct ID
2544
Source Match
DrugCentral (CAS), FDA GSRS (UNII)
Synonyms and normalized names
SUNITINIB MALATESutent
SOURCE EMBL-EBI ChEMBL 80 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

TargetActivity ValueAssaysOrganism
Focal adhesion kinase 1
Kinase
Kd 6.36 - Homo sapiens
Tyrosine-protein kinase HCK
Kinase
Kd 6.06 - Homo sapiens
Tyrosine-protein kinase JAK3
Kinase
Kd 5.92 - Homo sapiens
Potassium voltage-gated channel subfamily H member 2
Ion channel
IC50 6.3 - Homo sapiens
ATP-binding cassette sub-family G member 2
Transporter
IC50 5.52 - Homo sapiens
Acetylcholinesterase
Enzyme
IC50 5.23 - Homo sapiens
Ribosyldihydronicotinamide dehydrogenase [quinone]
Enzyme
Kd 5.4 - Homo sapiens
Platelet-derived growth factor receptor beta
Kinase
Kd 10.12 - Homo sapiens
Tyrosine-protein kinase ABL1
Kinase
Kd 7.26 - Homo sapiens
Mast/stem cell growth factor receptor Kit
Kinase
Kd 9.68 - Homo sapiens
Epidermal growth factor receptor
Kinase
Kd 6.07 - Homo sapiens
Pyridoxal kinase
Kinase
Kd 5.22 - Homo sapiens
Proto-oncogene tyrosine-protein kinase Src
Kinase
Kd 5.68 - Homo sapiens
Tyrosine-protein kinase Lck
Kinase
Kd 6.64 - Homo sapiens
Tyrosine-protein kinase Yes
Kinase
Kd 6.92 - Homo sapiens
Tyrosine-protein kinase Fyn
Kinase
Kd 6.28 - Homo sapiens
Receptor-type tyrosine-protein kinase FLT3
Kinase
Kd 9.66 - Homo sapiens
Vascular endothelial growth factor receptor 2
Kinase
Kd 9.7 - Homo sapiens
Vascular endothelial growth factor receptor 3
Kinase
Ki 7.77 - Homo sapiens
Macrophage colony-stimulating factor 1 receptor
Kinase
Kd 8.7 - Homo sapiens
Ribosomal protein S6 kinase alpha-3
Kinase
Kd 7.26 - Homo sapiens
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Kinase
Kd 8.23 - Homo sapiens
Insulin-like growth factor 1 receptor
Kinase
Kd 5.59 - Homo sapiens
Myosin light chain kinase, smooth muscle
Kinase
Kd 7.64 - Homo sapiens
Insulin receptor
Kinase
Kd 6.74 - Homo sapiens
Death-associated protein kinase 3
Kinase
Kd 7.66 - Homo sapiens
Calcium/calmodulin-dependent protein kinase type 1
Kinase
Kd 6.01 - Homo sapiens
Fibroblast growth factor receptor 3
Kinase
Kd 6.54 - Homo sapiens
Rho-associated protein kinase 1
Kinase
Kd 6.34 - Homo sapiens
Tyrosine-protein kinase JAK1
Kinase
Kd 8.05 - Homo sapiens
Mitogen-activated protein kinase 10
Kinase
Kd 5.37 - Homo sapiens
Death-associated protein kinase 2
Kinase
Kd 6.82 - Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Kinase
IC50 4.92 - Homo sapiens
High affinity nerve growth factor receptor
Kinase
Kd 7 - Homo sapiens
Tyrosine-protein kinase JAK2
Kinase
Kd 6.39 - Homo sapiens
Rho-associated protein kinase 2
Kinase
Kd 6.85 - Homo sapiens
Protein kinase C alpha type
Kinase
Kd 5.22 - Homo sapiens
Calcium/calmodulin-dependent protein kinase type II subunit delta
Kinase
Kd 6.38 - Homo sapiens
Myosin light chain kinase 2, skeletal/cardiac muscle
Kinase
Kd 7.31 - Homo sapiens
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Kinase
Kd 6.36 - Homo sapiens
AP2-associated protein kinase 1
Kinase
Kd 7.96 - Homo sapiens
Serine/threonine-protein kinase MARK2
Kinase
Kd 6.51 - Homo sapiens
Hepatocyte growth factor receptor
Kinase
Kd 5.92 - Homo sapiens
Tyrosine-protein kinase Lyn
Kinase
Kd 6.57 - Homo sapiens
Serine/threonine-protein kinase Nek2
Kinase
Kd 6.3 - Homo sapiens
Ribosomal protein S6 kinase alpha-2
Kinase
Kd 7.77 - Homo sapiens
5'-AMP-activated protein kinase catalytic subunit alpha-1
Kinase
Kd 7.72 - Homo sapiens
Calcium/calmodulin-dependent protein kinase type II subunit beta
Kinase
Kd 5.85 - Homo sapiens
Fibroblast growth factor receptor 1
Kinase
Kd 6.28 - Homo sapiens
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Kinase
Kd 8.26 - Homo sapiens
SOURCE DrugCentral 80 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PTDrug AE LLRMedDRA
Disease progression 2387 3715.106 10061818
Neoplasm progression 1097 2358.96 10061309
Palmar-plantar erythrodysaesthesia syndrome 986 2354.256 10033553
Death 2753 1859.277 10011906
Dysgeusia 705 1101.274 10013911
Yellow skin 272 895.114 10048245
Diarrhoea 2387 831.254 10012735
Hypothyroidism 550 792.318 10021114
Oral pain 449 771.421 10031009
Stomatitis 807 677.445 10042128
Hair colour changes 222 665.187 10019030
Decreased appetite 1139 566.828 10061428
Drug ineffective 292 564.086 10013709
Thrombocytopenia 970 552.286 10043554
Hypertension 1135 550.423 10020772
Platelet count decreased 790 519.658 10035528
Osteonecrosis of jaw 389 513.744 10064658
Fatigue 2162 451.019 10016256
Ageusia 255 418.599 10001480
Mucosal inflammation 409 357.342 10028116
Asthenia 1199 333.929 10003549
Dry skin 344 269.384 10013786
Second primary malignancy 165 241.492 10039801
Rheumatoid arthritis 3 240.117 10039073
Off label use 410 234.048 10053762
Bone marrow failure 263 222.386 10065553
Epistaxis 386 216.152 10015090
Pleural effusion 442 205.859 10035598
Blood pressure increased 595 205.284 10005750
Skin discolouration 233 196.302 10040829
Dehydration 609 194.79 10012174
Dyspepsia 377 184.042 10013946
Malignant neoplasm progression 419 181.525 10051398
Nausea 1639 180.678 10028813
Therapeutic product effect decreased 4 180.581 10082201
Drug hypersensitivity 57 177.723 10013700
Arthropathy 15 175.658 10003285
Blood thyroid stimulating hormone increased 112 172.897 10005833
Completed suicide 7 167.823 10010144
Skin exfoliation 240 164.357 10040844
Renal cell carcinoma 96 160.385 10067946
Oral discomfort 105 151.8 10030973
Hypersensitivity 66 139.878 10020751
Vomiting 1145 139.062 10047700
Intentional product use issue 14 138.691 10076308
Hyperkeratosis 92 137.787 10020649
Sinusitis 31 131.708 10040753
Joint swelling 89 127.83 10023232
Arthralgia 278 127.292 10003239
Treatment failure 34 124.176 10066901

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE IUPHAR/BPS 11 interactions

IUPHAR Ligand-Target Data

Curated ligand-target interaction rows with action, affinity, and literature identifiers.

TargetAction AffinityPubMed
KIT proto-oncogene, receptor tyrosine kinase
KIT
Inhibition 7.880000114440918 pIC50 20570526
KIT proto-oncogene, receptor tyrosine kinase
KIT
Inhibition 9.430000305175781 pKd 22037378
fms related receptor tyrosine kinase 4
FLT4
Inhibition 8.050000190734863 pIC50 20570526
platelet derived growth factor receptor beta
PDGFRB
Inhibition 8.100000381469727 pKi 12538485
platelet derived growth factor receptor beta
PDGFRB
Inhibition 8.199999809265137 pIC50 23279183
fibroblast growth factor receptor 1
FGFR1
Inhibition 6.079999923706055 pKi 12538485
fms related receptor tyrosine kinase 3
FLT3
Inhibition 8.1899995803833 pIC50 20570526
kinase insert domain receptor
KDR
Inhibition 7.650000095367432 pIC50 20570526
large tumor suppressor kinase 1
LATS1
Inhibition 6.199999809265137 pKd -
large tumor suppressor kinase 2
LATS2
Inhibition 6.340000152587891 pKd 19654408
ret proto-oncogene
RET
Inhibition 8.800000190734863 pIC50 23279183
SOURCE PharmGKB 60 phenotype rows

Pharmacogenomics

Drug-gene phenotype annotations and evidence levels from PharmGKB-mapped rows.

FLT3 (PA28181) rs1933437
Genotypes AG + GG is associated with decreased likelihood of Thrombocytopenia when treated with sunitinib in people with Carcinoma, Renal Cell or Gastrointestinal Stromal Tumors as compared to genotype AA.
Evidence: -; PMID 20683446
CXCL8 (PA29841) rs1126647
Allele T is associated with decreased overall survival when treated with pazopanib or sunitinib in people with Carcinoma, Renal Cell as compared to allele A.
Evidence: -; PMID 25695485
NR1I3 (PA391) rs2307424
Genotypes AA + AG is associated with decreased overall survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype GG.
Evidence: -; PMID 23462807
ABCB1 (PA267) rs2032582
Genotypes AA + AT is associated with decreased overall survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotypes AC + CC.
Evidence: -; PMID 24874929
KDR (PA30086) rs34231037
Genotype AG is associated with increased clinical benefit to sunitinib as compared to genotype GG.
Evidence: -; PMID 28430711
CYP3A5 (PA131) rs776746
Genotype TT is associated with increased risk of dose reductions due to toxicity when treated with sunitinib in people with Carcinoma, Renal Cell as compared to allele C.
Evidence: -; PMID 22015057
FLT4 (PA28183) rs307821
Genotype AC is associated with decreased progression-free survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype CC.
Evidence: -; PMID 22015057
FLT4 (PA28183) rs307826
Genotype CT is associated with reduced progression-free survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype TT.
Evidence: -; PMID 22015057
FLT1 (PA28180) rs9582036
Genotype CC is associated with decreased overall survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotypes AA + AC.
Evidence: -; PMID 26935927
FLT1 (PA28180) rs9554320
Genotype AA is associated with decreased overall survival and progression-free survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotypes AC + CC.
Evidence: -; PMID 23421954
SLC22A5 (PA333) rs2631370
Allele C is associated with decreased overall survival when treated with sunitinib in people with Gastrointestinal Stromal Tumors as compared to allele T.
Evidence: -; PMID 28117434
ABCB1 (PA267) rs1045642
Genotypes AA + AG is associated with increased clearance of sunitinib in people with Carcinoma, Renal Cell and Neoplasm Metastasis as compared to genotype GG.
Evidence: -; PMID 27485537
FLT4 (PA28183) rs307821
Genotypes AA + AC is associated with decreased progression-free survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype CC.
Evidence: -; PMID 23462807
VEGFA (PA37302) rs833061
Allele C is associated with increased systolic blood pressure and increased risk of developing grade 3 hypertension when treated with sunitinib as compared to allele T.
Evidence: -; PMID 22948895
VEGFA (PA37302) rs699947
Allele A is associated with increased systolic blood pressure and increased risk of developing grade 3 hypertension when treated with sunitinib as compared to allele C.
Evidence: -; PMID 22948895
VEGFA (PA37302) rs2010963
Allele G is associated with increased systolic blood pressure and increased risk of developing grade 3 hypertension when treated with sunitinib as compared to allele C.
Evidence: -; PMID 22948895
NOS3 (PA254) rs2070744
Genotypes CC + CT are associated with increased risk of grade 3 hypertension when treated with sunitinib as compared to genotype TT.
Evidence: -; PMID 22948895
ABCB1 (PA267) rs1045642
Genotype GG is associated with decreased response to sunitinib in people with Carcinoma, Renal Cell as compared to genotypes AA + AG.
Evidence: -; PMID 25778465
ABCB1 (PA267) rs1045642
Genotype GG is associated with increased exposure to sunitinib in people with Carcinoma, Renal Cell as compared to genotypes AA + AG.
Evidence: -; PMID 25778465
KDR (PA30086) rs1870377
Allele A is not associated with Drug Toxicity when treated with sunitinib in people with Carcinoma, Renal Cell as compared to allele T.
Evidence: -; PMID 24013576
PDGFRA (PA33147) rs35597368
Genotypes CC + CT is not associated with overall survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype TT.
Evidence: -; PMID 24013576
ABCG2 (PA390) rs2231142
Genotype TT is associated with increased risk of Thrombocytopenia when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotypes GG + GT.
Evidence: -; PMID 24013576
ABCG2 (PA390) rs2231142
Genotype TT is associated with increased risk of Neutropenia when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotypes GG + GT.
Evidence: -; PMID 24013576
KDR (PA30086) rs2305948
Allele C is not associated with Drug Toxicity when treated with sunitinib in people with Carcinoma, Renal Cell as compared to allele T.
Evidence: -; PMID 24013576
CYP3A5 (PA131) rs776746
Allele C is not associated with Drug Toxicity when treated with sunitinib in people with Carcinoma, Renal Cell as compared to allele T.
Evidence: -; PMID 24013576
RET (PA34335) rs1799939
Genotypes AA + AG is not associated with overall survival when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype GG.
Evidence: -; PMID 24013576
FLT3 (PA28181) rs1933437
Allele A is not associated with Drug Toxicity when treated with sunitinib in people with Carcinoma, Renal Cell as compared to allele G.
Evidence: -; PMID 24013576
CYP1A1 (PA27092) rs1048943
Genotype A is not associated with Drug Toxicity when treated with sunitinib in people with Carcinoma, Renal Cell as compared to genotype G.
Evidence: -; PMID 24013576
ABCB1 (PA267) rs2032582
Genotype AA is associated with decreased response to sunitinib in people with Carcinoma, Renal Cell.
Evidence: -; PMID 26244574
FLT3 (PA28181) rs1933437
Genotype AA is not associated with response to sunitinib in people with Carcinoma, Renal Cell as compared to genotypes AG + GG.
Evidence: -; PMID 26244574
SOURCE NLM RxNorm 7 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

NameRxCUI TypeSource
SUNITINIB 357977 SU MTHSPL
SUNITINIB MALATE 616275 SU MTHSPL
sunitinib 357977 IN RXNORM
SUNItinib 357977 TMSY RXNORM
Sutent 616274 BN RXNORM
sunitinib malate 616275 PIN RXNORM
SUNItinib malate 616275 TMSY RXNORM
SOURCE SIDER 80 side-effect rows

Side Effects

SIDER side-effect terms mapped to the drug or same-CAS compound identity.

Side EffectDrug Name MedDRA TypeConcept ID
Abdominal abscess sunitinib LLT C0243001
Abdominal abscess sunitinib PT C0243001
Abdominal discomfort sunitinib LLT C0232487
Abdominal discomfort sunitinib PT C0232487
Abdominal distension sunitinib LLT C0000731
Abdominal distension sunitinib PT C0000731
Abdominal pain sunitinib LLT C0000737
Abdominal pain sunitinib PT C0000737
Abdominal pain upper sunitinib LLT C0232492
Abdominal pain upper sunitinib PT C0232492
Abdominal sepsis sunitinib LLT C1141926
Abdominal sepsis sunitinib PT C1141926
Abscess sunitinib LLT C0000833
Abscess sunitinib PT C0000833
Abscess limb sunitinib LLT C0578455
Abscess limb sunitinib PT C0578455
Acalculous cholecystitis sunitinib LLT C0267841
Acne sunitinib LLT C0702166
Acne sunitinib PT C0702166
Acute coronary syndrome sunitinib LLT C0948089
Acute coronary syndrome sunitinib PT C0948089
Adrenal insufficiency sunitinib LLT C0001623
Adrenal insufficiency sunitinib PT C0001623
Ageusia sunitinib LLT C2364111
Ageusia sunitinib PT C2364111
Alanine aminotransferase increased sunitinib LLT C0151905
Alanine aminotransferase increased sunitinib PT C0151905
Albumin low sunitinib LLT C0860864
Alertness decreased sunitinib LLT C0877609
Alopecia sunitinib LLT C0002170
Alopecia sunitinib PT C0002170
Amylase increased sunitinib LLT C0151479
Amylase increased sunitinib PT C0151479
Anaemia sunitinib LLT C0002871
Anaemia sunitinib PT C0002871
Anal abscess sunitinib LLT C0281778
Anal abscess sunitinib PT C0281778
Anal fistula sunitinib LLT C0205929
Anal fistula sunitinib PT C0205929
Angioedema sunitinib LLT C0002994
Angioedema sunitinib PT C0002994
Angiopathy sunitinib LLT C0042373
Angiopathy sunitinib PT C0042373
Anorexia sunitinib LLT C0003123
Aphthous stomatitis sunitinib LLT C0038363
Aphthous stomatitis sunitinib PT C0038363
Apoptosis sunitinib LLT C0162638
Apoptosis sunitinib PT C0162638
Arrhythmia sunitinib LLT C0003811
Arrhythmia sunitinib PT C0003811
Arthralgia sunitinib LLT C0003862
Arthralgia sunitinib PT C0003862
Aspartate aminotransferase increased sunitinib LLT C0151904
Aspartate aminotransferase increased sunitinib PT C0151904
Asthenia sunitinib LLT C0004093
Asthenia sunitinib PT C0004093
Asthenia sunitinib PT C0004093
Back pain sunitinib LLT C0004604
Back pain sunitinib PT C0004604
Bacterial infection sunitinib LLT C0004623
Bacterial infection sunitinib PT C0004623
Bilirubin total increased sunitinib LLT C0741494
Blindness sunitinib PT C0456909
Blindness cortical sunitinib LLT C0155320
Blindness cortical sunitinib PT C0155320
Blister sunitinib LLT C0005758
Blister sunitinib PT C0005758
Blood albumin decreased sunitinib PT C0853777
Blood alkaline phosphatase increased sunitinib PT C0852911
Blood and lymphatic system disorders sunitinib - C0851353
Blood bilirubin increased sunitinib LLT C0311468
Blood bilirubin increased sunitinib PT C0311468
Blood bilirubin increased sunitinib PT C0311468
Blood calcium decreased sunitinib PT C3665624
Blood creatinine increased sunitinib PT C0235431
Blood creatinine increased sunitinib LLT C0235431
Blood creatinine increased sunitinib PT C0235431
Blood disorder sunitinib LLT C0018939
Blood disorder sunitinib PT C0018939
Blood glucose decreased sunitinib PT C0595883
SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Sunitinib used for in pharmaceutical contexts?

Sunitinib (CAS 557795-19-4) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Sunitinib?

Sunitinib has 498 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Disease progression, Neoplasm progression, Palmar-plantar erythrodysaesthesia syndrome, Death, Dysgeusia. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Sunitinib also used in cosmetics?

No same-CAS cosmetics profile is rendered from the ingredients-table cross-reference for Sunitinib.

What clinical phase is Sunitinib in?

No phase 1-4 clinical development badge is rendered for Sunitinib because the matched compound identifier rows do not contain a max-phase value.

What bioactivity targets are documented for Sunitinib?

Sunitinib has 283 bioactivity rows in this page query. Rendered target entries include Focal adhesion kinase 1, Tyrosine-protein kinase HCK, Tyrosine-protein kinase JAK3, Potassium voltage-gated channel subfamily H member 2, ATP-binding cassette sub-family G member 2.