OralDosed ingredientTherapeutic flag
Cosmetic cross-reference
Isotretinoin
CAS 4759-48-2
Isotretinoin (CAS 4759-48-2) is a Phase 4 pharmaceutical compound with 13 bioactivity targets and 1,412 adverse event associations.
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NLM DailyMed
Label records
0
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EMBL-EBI ChEMBL
Bioactivity
19
SOURCE
DrugCentral
Adverse signals
1,412
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IUPHAR/BPS
PubMed IDs
0
SOURCE
EMBL-EBI ChEMBL
B25820EEF0F0
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Primary Name
Isotretinoin
CAS Number
4759-48-2
UNII
EH28UP18IF
InChIKey
SHGAZHPCJJPHSC-XFYACQKRSA-N
ChEMBL ID
CHEMBL547
Molecule Type
Small molecule
Source Match
EMBL-EBI ChEMBL (INCHIKEY)
Synonyms and normalized names
Accutane
black box warningdosed ingredientnatural productoraltherapeutic flag
SOURCE
EMBL-EBI ChEMBL
B25820EEF0F0
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Phase 4 (Approved)
Approved or marketed human pharmaceutical use is represented in the source phase field.
ChEMBL CHEMBL547 | Small molecule
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Ingredients table / CosIng profile
same-CAS cross-reference
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
SOURCE
EMBL-EBI ChEMBL
19 bioactivity rows
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | Potency | 21999.298360655735 nM | 49 | - |
| - | AC50 | 28729.065625 nM | 32 | - |
| - | IC50 | 15726.06 nM | 28 | - |
| - | Ki | 6479 nM | 4 | - |
| - | Kd | 200 nM | 2 | - |
| - | EC50 | 4400 nM | 1 | - |
| 5-hydroxytryptamine receptor 2B GPCR |
Ki | 6.268 | - | Homo sapiens |
| Alpha-2B adrenergic receptor GPCR |
Ki | 5.52 | - | Homo sapiens |
| Adenosine receptor A3 GPCR |
Ki | 5.628 | - | Homo sapiens |
| Retinoic acid receptor alpha Nuclear hormone receptor |
ED50 | 8.229 | - | Homo sapiens |
| Alcohol dehydrogenase 4 Enzyme |
Ki | 5.523 | - | Homo sapiens |
| Dehydrogenase/reductase SDR family member 9 Enzyme |
Ki | 4.523 | - | Homo sapiens |
| 11-cis retinol dehydrogenase Enzyme |
Ki | 7 | - | Homo sapiens |
| 17-beta-hydroxysteroid dehydrogenase type 6 Enzyme |
Ki | 5.398 | - | Homo sapiens |
| Retinoic acid receptor beta Nuclear hormone receptor |
INHIBITOR | - | - | Homo sapiens |
| Mitogen-activated protein kinase 14 Kinase |
IC50 | 5.597 | - | Homo sapiens |
| Mitogen-activated protein kinase 1 Kinase |
IC50 | 6.335 | - | Homo sapiens |
| Cellular retinoic acid-binding protein 1 Cytosolic other |
IC50 | 6.05 | - | Gallus gallus |
| Olfactory receptor 51E2 GPCR |
IC50 | 6.8 | - | Homo sapiens |
SOURCE
DrugCentral
80 associations
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Unintended pregnancy | 1470 | 7747.662 | 10045542 |
| Abortion induced | 960 | 3990.61 | 10000220 |
| Pregnancy | 1198 | 3804.475 | 10036556 |
| Depression | 2024 | 3514.697 | 10012378 |
| Exposure during pregnancy | 1647 | 3275.462 | 10073513 |
| Mood altered | 808 | 2623.334 | 10027940 |
| Suicidal ideation | 1063 | 2241.689 | 10042458 |
| Blood triglycerides increased | 688 | 2053.175 | 10005839 |
| Dry skin | 847 | 1732.572 | 10013786 |
| Lip dry | 493 | 1477.601 | 10024552 |
| Treatment noncompliance | 695 | 1458.548 | 10049414 |
| No adverse event | 695 | 1353.826 | 10067482 |
| Mood swings | 402 | 1000.557 | 10027951 |
| Abortion spontaneous | 404 | 775.611 | 10000234 |
| Pregnancy test false positive | 113 | 678.893 | 10036573 |
| Cheilitis | 212 | 677.69 | 10008417 |
| Adverse drug reaction | 460 | 570.413 | 10061623 |
| Chapped lips | 154 | 555.79 | 10049047 |
| Depressed mood | 329 | 498.072 | 10012374 |
| Xerosis | 119 | 459.697 | 10048222 |
| Anxiety | 656 | 444.182 | 10002855 |
| Epistaxis | 410 | 415.204 | 10015090 |
| Acne fulminans | 76 | 411.628 | 10049141 |
| Sacroiliitis | 135 | 401.486 | 10039361 |
| Dry eye | 260 | 368.81 | 10013774 |
| Headache | 1067 | 360.779 | 10019211 |
| Epiphyses premature fusion | 62 | 341.902 | 10015078 |
| Anger | 185 | 332.139 | 10002368 |
| Arthralgia | 962 | 315.295 | 10003239 |
| Drug exposure before pregnancy | 77 | 303.351 | 10064998 |
| Selective abortion | 54 | 299.22 | 10067499 |
| Pregnancy on oral contraceptive | 74 | 297.28 | 10036567 |
| Myalgia | 463 | 297.222 | 10028411 |
| Inflammatory bowel disease | 119 | 296.14 | 10021972 |
| Suicide attempt | 290 | 272.678 | 10042464 |
| Normal newborn | 114 | 269.19 | 10029769 |
| Self-injurious ideation | 91 | 251.581 | 10051154 |
| Pneumonia | 50 | 251.007 | 10035664 |
| Acne | 174 | 243.453 | 10000496 |
| Crying | 158 | 234.909 | 10011469 |
| Adverse event | 253 | 219.439 | 10060933 |
| Maternal exposure during pregnancy | 407 | 214.934 | 10071408 |
| Acute kidney injury | 20 | 212.655 | 10069339 |
| Irritability | 195 | 212.571 | 10022998 |
| Dyspnoea | 129 | 206.268 | 10013968 |
| Fall | 25 | 204.746 | 10016173 |
| Infectious mononucleosis | 67 | 196.518 | 10021914 |
| Exposure via body fluid | 50 | 190.754 | 10073300 |
| Idiopathic intracranial hypertension | 72 | 190.39 | 10078904 |
| Blood cholesterol increased | 262 | 188.689 | 10005425 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
SOURCE
NLM RxNorm
5 name rows
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| Isotretinoin | 6064 | SU | MTHSPL |
| ISOTRETINOIN | 6064 | SU | MTHSPL |
| isotretinoin | 6064 | IN | RXNORM |
| ISOtretinoin | 6064 | TMSY | RXNORM |
| Accutane | 202795 | BN | RXNORM |
SOURCE
SIDER
80 side-effect rows
Side Effects
SIDER side-effect terms mapped to the drug or same-CAS compound identity.
| Side Effect | Drug Name | MedDRA Type | Concept ID |
|---|---|---|---|
| Abdominal pain | retinoic | LLT | C0000737 |
| Abdominal pain | retinoic | PT | C0000737 |
| Abnormal behaviour | retinoic | PT | C0233514 |
| Abnormalities of the hair | retinoic | LLT | C0157733 |
| Acne | retinoic | LLT | C0702166 |
| Acne | retinoic | PT | C0702166 |
| Acne fulminans | retinoic | LLT | C0263445 |
| Acne fulminans | retinoic | PT | C0263445 |
| Affect lability | retinoic | PT | C0233472 |
| Aggression | retinoic | LLT | C0001807 |
| Aggression | retinoic | PT | C0001807 |
| Aggression | retinoic | PT | C0001807 |
| Aggression | retinoic | PT | C0001807 |
| Agranulocytosis | retinoic | LLT | C0001824 |
| Agranulocytosis | retinoic | PT | C0001824 |
| Allergic cutaneous angiitis | retinoic | LLT | C0151436 |
| Alopecia | retinoic | LLT | C0002170 |
| Alopecia | retinoic | PT | C0002170 |
| Alopecia | retinoic | PT | C0002170 |
| Alopecia reversible | retinoic | LLT | C0858678 |
| Anaemia | retinoic | LLT | C0002871 |
| Anaemia | retinoic | PT | C0002871 |
| Anaphylactic shock | retinoic | LLT | C0002792 |
| Anaphylactic shock | retinoic | PT | C0002792 |
| Anger | retinoic | LLT | C0002957 |
| Anger | retinoic | PT | C0002957 |
| Anxiety | retinoic | LLT | C0003467 |
| Anxiety | retinoic | PT | C0003467 |
| Application site erythema | retinoic | LLT | C0853700 |
| Application site erythema | retinoic | PT | C0853700 |
| Application site pain | retinoic | PT | C0521491 |
| Application site pruritus | retinoic | LLT | C0853714 |
| Application site pruritus | retinoic | PT | C0853714 |
| Application site stinging | retinoic | LLT | C2721737 |
| Arthralgia | retinoic | LLT | C0003862 |
| Arthralgia | retinoic | PT | C0003862 |
| Arthritis | retinoic | LLT | C0003864 |
| Arthritis | retinoic | PT | C0003864 |
| Asthenia | retinoic | LLT | C0004093 |
| Asthenia | retinoic | PT | C0004093 |
| Asthenia | retinoic | PT | C0004093 |
| Asthenopia | retinoic | LLT | C0004095 |
| Asthenopia | retinoic | PT | C0004095 |
| Asthma | retinoic | LLT | C0004096 |
| Asthma | retinoic | PT | C0004096 |
| Auditory disorder NOS | retinoic | LLT | C0260662 |
| Back pain | retinoic | LLT | C0004604 |
| Back pain | retinoic | PT | C0004604 |
| Behavior disorder | retinoic | LLT | C0004930 |
| Benign intracranial hypertension | retinoic | LLT | C0033845 |
| Benign intracranial hypertension | retinoic | PT | C0033845 |
| Blepharitis | retinoic | LLT | C0005741 |
| Blepharitis | retinoic | PT | C0005741 |
| Blood alkaline phosphatase increased | retinoic | PT | C0852911 |
| Blood alkaline phosphatase increased | retinoic | LLT | C0852911 |
| Blood alkaline phosphatase increased | retinoic | PT | C0852911 |
| Blood bilirubin increased | retinoic | LLT | C0311468 |
| Blood bilirubin increased | retinoic | PT | C0311468 |
| Blood cholesterol increased | retinoic | LLT | C0595930 |
| Blood cholesterol increased | retinoic | PT | C0595930 |
| Blood creatine phosphokinase increased | retinoic | PT | C0853034 |
| Blood creatine phosphokinase increased | retinoic | PT | C0853034 |
| Blood glucose increased | retinoic | LLT | C0595877 |
| Blood glucose increased | retinoic | PT | C0595877 |
| Blood lactate dehydrogenase increased | retinoic | PT | C0853149 |
| Blood triglycerides increased | retinoic | PT | C0853692 |
| Blood triglycerides increased | retinoic | LLT | C0853692 |
| Blood triglycerides increased | retinoic | PT | C0853692 |
| Blood uric acid increased | retinoic | PT | C0235416 |
| Bronchospasm | retinoic | LLT | C0006266 |
| Bronchospasm | retinoic | PT | C0006266 |
| Cardiovascular disorder | retinoic | LLT | C0007222 |
| Cardiovascular disorder | retinoic | PT | C0007222 |
| Cataract | retinoic | LLT | C0086543 |
| Cataract | retinoic | PT | C0086543 |
| Central nervous system disorder | retinoic | LLT | C0007682 |
| Cerebrovascular accident | retinoic | LLT | C0038454 |
| Cerebrovascular accident | retinoic | PT | C0038454 |
| Chapped lips | retinoic | LLT | C0424489 |
| Chapped lips | retinoic | PT | C0424489 |
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Rendered pharma page rows
FAQPage JSON-LD
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Isotretinoin used for in pharmaceutical contexts?
Isotretinoin (CAS 4759-48-2) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Isotretinoin?
Isotretinoin has 1,412 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Unintended pregnancy, Abortion induced, Pregnancy, Depression, Exposure during pregnancy. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Isotretinoin also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Isotretinoin Regulatory with EU status "permitted".
What clinical phase is Isotretinoin in?
Isotretinoin is rendered with ChEMBL max phase 4 (approved).
What bioactivity targets are documented for Isotretinoin?
Isotretinoin has 19 bioactivity rows in this page query. Rendered target entries include 5-hydroxytryptamine receptor 2B, Alpha-2B adrenergic receptor, Adenosine receptor A3, Retinoic acid receptor alpha, Alcohol dehydrogenase 4.