NOAEL Studies Cosmetic Ingredient

Zeolite NOAEL Studies

INCI: ZEOLITE

CAS: 1318-02-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1996 IARC Monographs {"additional_info":"volume_publication_year=1997","evaluation_year":1996,"source_table":"iarc_classifications","volume":"68"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1996 IARC Monographs {"additional_info":"volume_publication_year=1997","evaluation_year":1996,"source_table":"iarc_classifications","volume":"68"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1996 IARC Monographs {"additional_info":"volume_publication_year=1997","evaluation_year":1996,"source_table":"iarc_classifications","volume":"68"}
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=4983; Record_ID=cancer_6574; Data_Type=WOE; Formulation_Name=Zeolites; Mixture=Chemical; DTXSID=DTXSID4029640; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/86; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029640
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =960 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f550; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/6/2?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=bladder: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839267_15847801:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_651d587ae926c3b54a1ac640d0419a26
ToxValDB_ECHA_IUCLID NOAEL >=20 mg/m3 Rat inhalation - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c84ae4b0a7c65d217cf8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/8?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15817296:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad0927cb0b011b4541f8d3644f538b82
ToxValDB_ECHA_IUCLID NOAEL >=78 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d21699c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/8?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820349:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e01ea02c1621fa484003c9f3ac0d5164
ToxValDB_ECHA_IUCLID NOAEL >=1600 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d216e4b0a7c65d231792; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/9/3?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823375:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f8d77d538a008d7cfad807c59464595c
ToxValDB_ECHA_IUCLID NOAEL >=5000 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221e72; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/6/2?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15835864:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bcce2c335de70042b210fb78c63217fa
ToxValDB_ECHA_IUCLID NOAEL >=5900 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221e72; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/6/2?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15835865:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a12ccc0573b64733aea50f6e9fbf186
ToxValDB_ECHA_IUCLID NOAEL >=8000 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221e72; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/6/2?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15835866:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd9540f1c0e495cf309362b11bef68f9
ToxValDB_ECHA_IUCLID NOAEL =480 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f550; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15478/7/6/2?documentUUID=68920c66-05b2-4f6e-95d2-50e8a827da7e; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839267_15847801:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4613a4ea7efd2bd44a9e6574aa1d7a85
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634618:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ede7127093e797eb46fff0e673262e90