Is Xanthine safe in cosmetics?
Xanthine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Xanthine
Also known as: 1H-Purine-2,6-dione, 3,7-dihydro-, EINECS 200-718-6, Purine-2,6-(1H,3H)-dione, EPA Pesticide Chemical Code 116900, UNII-1AVZ07U9S7 (+13 more)
INCI: XANTHINE
Xanthine (CAS 69-89-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 69-89-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,7-dihydropurine-2,6-dione
InChIKey
LRFVTYWOQMYALW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; also a known biochemical (purine base) — no specific FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Xanthine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Xanthine.
Known Synonyms
1H-Purine-2,6-dione, 3,7-dihydro-
EINECS 200-718-6
Purine-2,6-(1H,3H)-dione
EPA Pesticide Chemical Code 116900
UNII-1AVZ07U9S7
2,6-dihydroxypurine
9H-purine-2,6-(1H,3H)-dione
Xan
9H-xanthine
2,3,6,7-tetrahydro-1H-purine-2,6-dione
2,6(1,3)-Purinedion
3,7-Dihydro-1H-purine-2,6-dione
3,7-Dihydropurine-2,6-dione
9H-Purine-2,6(1H,3H)-dione
9H-Purine-2,6-diol
Dioxopurine
Purine-2,6-diol
7H-xanthine
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; Pesticides
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
XANTHINE
ChEMBL ID
CHEMBL1424
Frequently Asked Questions
Is Xanthine allowed in the EU?
Xanthine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Xanthine do in cosmetics?
Xanthine functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 69-89-6.
Is Xanthine used outside cosmetics?
Xanthine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Xanthine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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