Is Wogonin safe in cosmetics?
Wogonin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Wogonin
Also known as: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-, BRN 0287152, 5,7-Dihydroxy-8-methoxyflavone, Vogonin, UNII-POK93PO28W (+2 more)
INCI: WOGONIN
Wogonin (CAS 632-85-9) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning; anti-inflammatory flavonoid from *Scutellaria. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 632-85-9 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning; anti-inflammatory flavonoid from *Scutellaria baicalensis*
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
InChIKey
XLTFNNCXVBYBSX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as cosmetic ingredient; no specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Wogonin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "632-85-9", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-inflammatory", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Bleaching agent
Expert Verdict
Expert safety assessment and concern-level summary for Wogonin.
Regulatory Flags
natural-origin
Known Synonyms
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-
BRN 0287152
5,7-Dihydroxy-8-methoxyflavone
Vogonin
UNII-POK93PO28W
5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
Norwogonin 8-methyl ether
Chemical Function
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
WOGONIN
ChEMBL ID
CHEMBL16171
Frequently Asked Questions
Is Wogonin allowed in the EU?
Wogonin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Wogonin do in cosmetics?
Wogonin functions as: Antioxidant, skin conditioning; anti-inflammatory flavonoid from *Scutellaria baicalensis*. It is classified as a cosmetic ingredient in our database. CAS number: 632-85-9.
Is Wogonin used outside cosmetics?
Wogonin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Wogonin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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