NOAEL Studies Antioxidant

Vitamin E Oil NOAEL Studies

INCI: TOCOPHERYL ACETATE

CAS: 7695-91-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =540 mg/day Human - - study with volunteers EFSA FEEDAP - 2010 - OutputID 178 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species - doi:10.2903/j.efsa.2010.1635
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=360 mg/kg bw/day Dog oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cbbb5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13377/7/6/2?documentUUID=0aa9da58-cced-45f2-aa27-f438d9244acd; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15849870:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_62678f96ccc70384b11b20729d284e63
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cbbd0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13377/7/6/2?documentUUID=0aa9da58-cced-45f2-aa27-f438d9244acd; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15849871:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d043b2269d02708658b014803c60fe8
ToxValDB_ECHA_IUCLID NOAEL =1600 mg/kg bw/day Hamster oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d224e4b0a7c65d231a6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13377/7/9/3?documentUUID=0aa9da58-cced-45f2-aa27-f438d9244acd; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15822433:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df3b8f9fbe3ec08f5171e7451f409c13
ToxValDB_ECHA_IUCLID NOAEL >2000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b477a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13377/7/8?documentUUID=0aa9da58-cced-45f2-aa27-f438d9244acd; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15820219:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fcbfda345c7686ccb28fb1e160422b6c
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =540 mg/day Human oral - epidemiologic LONG_REF=EFSA FEEDAP (2010). Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species. doi:10.2903/j.efsa.2010.1635.; TITLE=Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2010.1635; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15614236:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c17f496dfa645478e4db2619a07e124e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =73.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635279:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1594cb196816e165a2fd1f781bdd68e
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9E8X80D2L0 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"9E8X80D2L0"}
openFDA substances FDA UNII substance identifier 9E8X80D2L0 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"9E8X80D2L0"}
openFDA substances FDA UNII substance identifier 9E8X80D2L0 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"9E8X80D2L0"}
openFDA substances FDA UNII substance identifier 9E8X80D2L0 UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"9E8X80D2L0"}
openFDA substances FDA UNII substance identifier WR1WPI7EW8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C31H52O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WR1WPI7EW8"}
openFDA substances FDA UNII substance identifier WR1WPI7EW8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C31H52O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WR1WPI7EW8"}
openFDA substances FDA UNII substance identifier WR1WPI7EW8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C31H52O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WR1WPI7EW8"}
openFDA substances FDA UNII substance identifier WR1WPI7EW8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C31H52O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WR1WPI7EW8"}