NOAEL Studies Cosmetic Ingredient

Vinyl Acetate NOAEL Studies

INCI: VINYL ACETATE

CAS: 108-05-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

ATSDR_toxval_ATSDR_MRLs.xlsx 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =102.463 mg/m3 Rat (Sprague-Dawley (Crl:CD BR); M) inhalation short-term; 5 days short-term ATSDR MRLs; row_hash=71c7d711c98c9986; source_hash=ToxValhc_e8d4dbd5f59d030ac44342a20d50d71b; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=29.1; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; doi=10.1080/089583797198178; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =702.808 mg/m3 Rat (Sprague-Dawley (Crl:CD BR); M) inhalation short-term; 5 days short-term ATSDR MRLs; row_hash=df78d1e86ebaefd0; source_hash=ToxValhc_27e6d8afa848e7ac2d885ccb1eda385e; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=199.6; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; doi=10.1080/089583797198178; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =76.0554 mg/m3 Rat (Sprague-Dawley (Crl:CD BR); M) inhalation short-term; 4 weeks short-term ATSDR MRLs; row_hash=32f68daf24ca8d9d; source_hash=ToxValhc_518fbdf38f4e067f7bb8fd573bb721fa; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=21.6; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; doi=10.1080/089583797198178; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =29.9996 mg/m3 Rat (Crl:CD(SD)BR Sprague-Dawley; M/F) inhalation chronic; 104 weeks chronic ATSDR MRLs; row_hash=662dd4bc00e67652; source_hash=ToxValhc_f254c4ef830324c978945d7b2df263af; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=8.52; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =173.941 mg/m3 Rat (Crl:CD(SD)BR Sprague-Dawley; M/F) inhalation chronic; 104 weeks chronic ATSDR MRLs; row_hash=9964306e706e3da1; source_hash=ToxValhc_a4d8d64b67d983ceb47f444991c80877; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=49.4; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e
California Proposition 65 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 2025-01-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2025-01-03","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 2025-01-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2025-01-03","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 2025-01-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2025-01-03","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 2025-01-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2025-01-03","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
EPA_IRIS_iris_rfc_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfc_systems.csv NOAEL (HEC) =5 mg/m^3 - inhalation chronic IRIS chronic inhalation RfC system PoD row_hash=07eceed9ba0678cb; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 5 mg/m^3; system=Nervous, Respiratory; basis=Nasal epithelial lesions; point_of_departure=NOAEL (HEC): 5 mg/m^3; composite_uf=30; confidence=High; dtxsid=DTXSID3021431; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; rfc_last_updated=10/01/1990; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0512_summary.pdf
EPA_IRIS_iris_rfc_systems.csv RfC =0.2 mg/m^3 - inhalation chronic IRIS chronic inhalation RfC system row_hash=91894804a2e98e67; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e-1; system=Nervous, Respiratory; basis=Nasal epithelial lesions; point_of_departure=NOAEL (HEC): 5 mg/m^3; composite_uf=30; confidence=High; dtxsid=DTXSID3021431; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; rfc_last_updated=10/01/1990; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0512_summary.pdf
IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 1995 IARC Monographs {"additional_info":"volume_publication_year=1995","evaluation_year":1995,"source_table":"iarc_classifications","volume":"Sup 7, 63"}
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 1995 IARC Monographs {"additional_info":"volume_publication_year=1995","evaluation_year":1995,"source_table":"iarc_classifications","volume":"Sup 7, 63"}
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 1995 IARC Monographs {"additional_info":"volume_publication_year=1995","evaluation_year":1995,"source_table":"iarc_classifications","volume":"Sup 7, 63"}
NTP_ICE_acute_inhalation 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 11.4 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1934; Record_ID=acute_inhalation_1131; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.4; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431
NTP_ICE_acute_inhalation LC50 11.3941 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1935; Record_ID=acute_inhalation_1907; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.3941; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431
NTP_ICE_acute_inhalation LC50 12.9495 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1936; Record_ID=acute_inhalation_1906; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.9495; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 2 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=3697; Record_ID=cancer_4253; Data_Type=WOE; Formulation_Name=Vinyl acetate; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/81; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431
ToxValDB_ATSDR_MRLs 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ATSDR_MRLs MRL =3.52108 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2023; ORIGINAL_YEAR=2023; TOXICOLOGICAL_EFFECT=respiratory in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447307_15447308_15447309:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89c2ebc36833ec2b045550a7772e9874
ToxValDB_ATSDR_MRLs MRL =2.46476 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2023; ORIGINAL_YEAR=2023; TOXICOLOGICAL_EFFECT=respiratory in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447307_15447308_15447309:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_30e8a0ea9db002d07981750e518eb9fc
ToxValDB_ATSDR_MRLs MRL =1.05632 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2023; ORIGINAL_YEAR=2023; TOXICOLOGICAL_EFFECT=respiratory in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447307_15447308_15447309:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aeed14b05be08d0042a5aceb85d268e2
ToxValDB_ATSDR_MRLs NOAEL =702.808 mg/m3 Rat inhalation short-term; 5 days short-term LONG_REF=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; TITLE=Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium; AUTHOR=Bogdanffy MS; DOI=10.1080/089583797198178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447888_15447889:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_27e6d8afa848e7ac2d885ccb1eda385e
ToxValDB_ATSDR_MRLs NOAEL =173.941 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447892_15447893:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a4d8d64b67d983ceb47f444991c80877
ToxValDB_ATSDR_MRLs NOAEL (HEC) =102.463 mg/m3 Rat inhalation short-term; 5 days short-term LONG_REF=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; TITLE=Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium; AUTHOR=Bogdanffy MS; DOI=10.1080/089583797198178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447888_15447889:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8d4dbd5f59d030ac44342a20d50d71b
ToxValDB_ATSDR_MRLs NOAEL (HEC) =76.0554 mg/m3 Rat inhalation short-term; 4 weeks short-term LONG_REF=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; TITLE=Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium; AUTHOR=Bogdanffy MS; DOI=10.1080/089583797198178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447890_15447891:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_518fbdf38f4e067f7bb8fd573bb721fa
ToxValDB_ATSDR_MRLs NOAEL (HEC) =29.9996 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447892_15447893:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f254c4ef830324c978945d7b2df263af
ToxValDB_Alaska_DEC 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Alaska_DEC RfC =0.2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445766:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=24368685d65971b1bb6db2a319e5b848
ToxValDB_Alaska_DEC RfC =0.2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445766:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=24368685d65971b1bb6db2a319e5b848
ToxValDB_Alaska_DEC RfD =0.0571 mg/kg bw/day Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445765:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0d55feb0e4a3cda5328e199f2a377bb6
ToxValDB_Alaska_DEC RfD =0.65 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445767:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ea88a7db2c9d8c8045c38063e7dfc21f
ToxValDB_Alaska_DEC RfD =1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445768:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1d366f6aa7a3591f2fb9881035a9a081
ToxValDB_Alaska_DEC RfD =0.0571 mg/kg bw/day Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445765:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0d55feb0e4a3cda5328e199f2a377bb6
ToxValDB_Alaska_DEC RfD =0.65 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445767:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ea88a7db2c9d8c8045c38063e7dfc21f
ToxValDB_Alaska_DEC RfD =1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445768:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1d366f6aa7a3591f2fb9881035a9a081
ToxValDB_Cal_OEHHA_REL_derivations 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Cal_OEHHA_REL_derivations NOAEL =176.054 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Bogdanffy MS, Dreef-van Der Meulen HC, Beems RB, Feron VJ, Cascier TC, Tyler TR, Vinegar MB, and Rickard RW. 1994. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam. Appl. Toxicol. 23:215-229.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Histological lesions of the nasal epithelium; STUDY_GROUP=Cal OEHHA REL derivations:15952155:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17e5e807e8ce154a1c9d3bb891c8f0fe
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =91548.1 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15521049:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b0a36bc2bb72109577e824960b7d723
ToxValDB_ECHA_IUCLID 25 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID BMDL (10) =477 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818451_15818452_15820281:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_80ec17d33b8078d42311c477c2dc0019
ToxValDB_ECHA_IUCLID LEL =14084.3 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/3/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15798173:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60a5efc9933e74aab841dd0e37d3d8a7
ToxValDB_ECHA_IUCLID LOAEL =3521.08 mg/m3 Rat inhalation - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ed97; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821451:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9b1a35d04f6ed79098cc7db2c11c101b
ToxValDB_ECHA_IUCLID NOAEC =704.216 mg/m3 Rat inhalation - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215eea; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15816145:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41ac8be65c32710b4bcfec1b75e10f71
ToxValDB_ECHA_IUCLID NOAEC =176.054 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828467_15828468:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7880f95d71c58f84f961f103f0d50eed
ToxValDB_ECHA_IUCLID NOAEC =528.162 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828931_15829289:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_128d0292401093c45c0bcc4b3e3e51e8
ToxValDB_ECHA_IUCLID NOAEL =1260 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816630_15820283:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1983122464efe1ef4face21f50a1504d
ToxValDB_ECHA_IUCLID NOAEL =223 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818016_15820285:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e18ce76b5120930186bcba2c38efec01
ToxValDB_ECHA_IUCLID NOAEL =6048 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816630_15820283:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_207d1d9df70c2831acefe31e35fe55ed
ToxValDB_ECHA_IUCLID NOAEL =5352 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818016_15820285:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a747d43971cc83bbefc9186d39e28a0
ToxValDB_ECHA_IUCLID NOAEL >=5000 ppm Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22eefc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15821672:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87206e3eddb424c50002b9a1e378e75d
ToxValDB_ECHA_IUCLID NOAEL >=100 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823291:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ba00594a771e67286d62d304d8a15054
ToxValDB_ECHA_IUCLID NOAEL =810 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15847271:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f941e944e66ab7d97adbfbbf21a4d27
ToxValDB_ECHA_IUCLID NOAEL =281 mg/kg bw/day Mouse oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15847505:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_152ab67e5ffa890378fc6d63c81901c0
ToxValDB_ECHA_IUCLID NOAEL =760 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15847904:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_365597123c563dcfe1048776ddff6b5b
ToxValDB_ECHA_IUCLID NOAEL =1325 mg/kg bw/day Mouse oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15848541:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4592bcc861908ae48021dd754d3679bb
ToxValDB_ECHA_IUCLID NOAEL =684 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15848595:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3c06fa7b4610aa74f18651af1fbaea5d
ToxValDB_ECHA_IUCLID NOAEL =285 mg/kg bw/day Mouse oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15848713:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6bbdfeb0d79b2b10561d29a290fc2a20
ToxValDB_ECHA_IUCLID NOAEL =202 mg/kg bw/day Mouse oral chronic; 104 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850315:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_531986b5da42a8bda5f777e110af69ba
ToxValDB_ECHA_IUCLID NOAEL =301 mg/kg bw/day Mouse oral chronic; 104 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850316:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_38f1143d8dee0e95f934ab52c02b7765
ToxValDB_ECHA_IUCLID NOAEL =146 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ff9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850318:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ef52908db2310b6b32aa8a4bc013bfb
ToxValDB_ECHA_IUCLID NOAEL =98 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ff9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850319:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_218d3f50c7dc80c6949bb797395ec30a
ToxValDB_ECHA_IUCLID NOAEL =1000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c891e4b0a7c65d21915e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15857252:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_675a92045dac9221e404dd99d13e33df
ToxValDB_ECHA_IUCLID NOEC =176.054 mg/m3 Mouse inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827556_15827557_15828943:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a526b3b7506248a003df7f1dfb28e843
ToxValDB_ECHA_IUCLID NOEL =1115 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cda; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818451_15818452_15820281:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9eb40883cac2ae7376fc640044a4b316
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA BMDL (10) =440 mg/kg bw/day Mouse oral - chronic LONG_REF=EFSA ANS (2013). Scientific Opinion on the safety of polyvinyl alcohol-polyethylene glycol-graft-co-polymer as a food additive. doi:10.2903/j.efsa.2013.3303.; TITLE=Scientific Opinion on the safety of polyvinyl alcohol-polyethylene glycol-graft-co-polymer as a food additive.; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2013.3303; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15622538:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c11c056f160082f256c595514230bbc9
ToxValDB_EPA_TSCA_8e 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =250 mg/kg bw/day Rabbit oral acute acute STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21160_Combined.pdf; TOXICOLOGICAL_EFFECT=decreased food consumption, decreased body weight, stomach foci; STUDY_GROUP=EPA TSCA 8e_dup_-_15956621_15956622:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8b67a366271f38f18e68b9da606d6707
ToxValDB_EPA_TSCA_8e LEL =500 mg/kg bw/day Rabbit oral acute acute STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21160_Combined.pdf; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EPA TSCA 8e_dup_-_15956621_15956622:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3daa74c4d63de93c59a0d00e60ff3d7
ToxValDB_EU_SCOEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EU_SCOEL NOAEL =35.2108 mg/m3 Human inhalation - occupational LONG_REF=ACGIH (1992) Vinyl acetate. In: Documentation of Threshold Limit Values and Biological Exposure Indices, 6th Edition. American Conference of Governmental Industrial Hygienists, Cincinnatti, OH.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d35a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/093_vinyl_acetate_oel_en.pdf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=irritancy; STUDY_GROUP=EU SCOEL:15952578:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5811464380e67b0c36d28d88598a78a7
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =17.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635668_15635669:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e9dc0039ec81d81329fcbc5efe8e08f8
ToxValDB_IRIS 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS LOAEL =704 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_063412a42f23c450e182b454153f7b4a
ToxValDB_IRIS LOAEL (ADJ) =126 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_29f80d6c623b81545be8c9d57744e390
ToxValDB_IRIS LOAEL (HEC) =19 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5b80d4f8ca65be667b366ba3e7341674
ToxValDB_IRIS NOAEL =176 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b6cb3223ebbc1062caffc8bd4d5d5c7b
ToxValDB_IRIS NOAEL (ADJ) =31 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cf8d479957aa358ce2853c7f9248e81e
ToxValDB_IRIS NOAEL (HEC) =5 mg/m3 Rat inhalation chronic; 104 weeks chronic LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_adc967a6daff03ae5c8bbc7e9c37c4d6
ToxValDB_TX_TCEQ 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_TX_TCEQ LOAEL =70.4216 mg/m3 Human inhalation acute; 240 minutes clinical LONG_REF=Smyth HF Jr, Carpenter CP. 1973; Vinyl acetate: Single animal inhalation and human sensory response. Carnegie Mellon University, Division of Sponsored Research, Chemical Hygiene Fellowship, Pittsburgh, PA. Special report f/36-72.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ab0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/vinylacetate.pdf; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Persistent slight throat irritation; STUDY_GROUP=TX TCEQ:15954726:-:-volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d046ea66748dc479ddac9c1dce70389
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier L9MK238N77 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L9MK238N77"}
openFDA substances FDA UNII substance identifier L9MK238N77 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L9MK238N77"}
openFDA substances FDA UNII substance identifier L9MK238N77 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L9MK238N77"}
openFDA substances FDA UNII substance identifier L9MK238N77 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L9MK238N77"}