NOAEL Studies Cosmetic Ingredient

Valproic Acid NOAEL Studies

INCI: VALPROIC ACID

CAS: 99-66-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing SQEdevelopmental listing type - - 1987-07-01 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"1987-07-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEdevelopmental listing type - - 1987-07-01 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"1987-07-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEdevelopmental listing type - - 1987-07-01 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"1987-07-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEdevelopmental listing type - - 1987-07-01 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"1987-07-01","listing_mechanism":"SQE","madl":null,"nsrl":null,"source_table":"prop65_listings"}
EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =600 mg/day Mammalian cell line - - - EFSA AFC - 2005 - OutputID 2122 - development - teratogenic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2005.246
EFSA NOAEL =600 mg/kg bw/day Unspecified - - - EFSA AFC - 2009 - OutputID 2306 - development - teratogenic - Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1) Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - doi:10.2903/j.efsa.2009.934
EFSA NOAEL =600 mg/day Mammalian cell line - - - EFSA AFC - 2005 - OutputID 2122 - development - teratogenic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2005.246
EFSA NOAEL =600 mg/kg bw/day Unspecified - - - EFSA AFC - 2009 - OutputID 2306 - development - teratogenic - Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1) Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - doi:10.2903/j.efsa.2009.934
NTP ICE adme parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 0.4366 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2466; Record_ID=adme_parameters_546; Data_Type=Measured; DTXSID=DTXSID6023733; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.4366; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6023733; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6023733
NTP ICE adme parameters Clint 4.6 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=2468; Record_ID=adme_parameters_546; Data_Type=Measured; DTXSID=DTXSID6023733; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=4.6; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6023733; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6023733
NTP ICE adme parameters Fu 0.214 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2465; Record_ID=adme_parameters_546; Data_Type=Measured; DTXSID=DTXSID6023733; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.214; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6023733; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6023733
NTP ICE adme parameters Fu 0.37 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=2467; Record_ID=adme_parameters_546; Data_Type=Measured; DTXSID=DTXSID6023733; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.37; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Pearce 2017; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6023733; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6023733
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=16280; RecordID=ARPathway2016_1821; DatasetName=ARPathway2016; DTXSID=DTXSID6023733; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6023733; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6023733
ECHA 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =159 mg/kg bw/day Mouse oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c84ae4b0a7c65d217cf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/8?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15816223:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0378cf9d3088108288cdad66b8fbdf3a
ECHA LEL =161 mg/kg bw/day Rat oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c84ae4b0a7c65d217cf6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/8?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15817294:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a639e4c9d8257e56c8c549f903f94688
ECHA LEL =163 mg/kg bw/day Mouse oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c84ae4b0a7c65d217cf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/8?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15816224:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_787b76efd101bd51d773161624b94677
ECHA LEL =172 mg/kg bw/day Rat oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c84ae4b0a7c65d217cf6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/8?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15817295:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b0d8570658a0e4edc3ac3e0547294ae8
ECHA LOAEL ~300 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1c0037; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/9/3?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15821628:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b47a9d9bd47783fad95e81a8a4d051ae
ECHA NOAEL =90 mg/kg bw/day Dog oral chronic; 12 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9ee4b0a7c65d1cea2a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/6/2?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15834025:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e018a0b1d9a2989698fafc1ba85a05e1
ECHA NOAEL ~100 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1c002d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/9/3?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820685:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f41d1a26bf7a44e87919ecaf40e2c3e6
ECHA NOAEL ~150 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1c0033; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/9/3?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821348:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f19fa575349171fe93df848134941500
ECHA NOAEL =152 mg/kg bw/day Rat oral chronic; 18 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9de4b0a7c65d1cea20; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/6/2?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15829863:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2d1b8efce3118bfdaf990efdd2ee3de
ECHA NOAEL =203 mg/kg bw/day Rat oral chronic; 18 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9de4b0a7c65d1cea20; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/6/2?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15829864:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d033aff6302b3093d2dfb26e04f81390
ECHA NOAEL =341 mg/kg bw/day Rat oral chronic; 6 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9de4b0a7c65d1cea23; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/6/2?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15833436:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ecae8ac28356cda306b8bbf1efe210fc
ECHA NOAEL =400 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1c002d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/9/3?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15822028:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_17d60953ee5d1b038e31c2d2f9cdd7e2
ECHA NOAEL =416 mg/kg bw/day Rat oral chronic; 6 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9de4b0a7c65d1cea23; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7482/7/6/2?documentUUID=073b1073-3ee6-40a7-9ef4-9f724882c649; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15833437:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d399efe2808f4f41616c1e9f37a61d44
ToxValDB ECOTOX 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =1.56 mmol/kg Rat oral acute; 0.75 days reproduction developmental LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595112_15598179_15604882_15604883:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7b20f46424dae698e71e6b657a066b0c
ToxValDB ECOTOX LOEL =3.13 mmol/kg Rat oral acute; 0.75 days reproduction developmental LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595112_15598179_15604882_15604883:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1947ee6fb54f62e11aa2d7eebb757687
ToxValDB ECOTOX LOEL =600 mg/kg bw/day Mouse oral short-term; 12 days developmental LONG_REF=J. Biochem. Mol. Toxicol.17(6): 346-356 Kawanishi,C.Y., P. Hartig, K.L. Bobseine, J. Schmid, M. Cardon, G. Massenburg, and N. Chernoff Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development 2003; TITLE=Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development; AUTHOR=Kawanishi,C.Y., P. Hartig, K.L. Bobseine, J. Schmid, M. Cardon, G. Massenburg, and N. Chernoff; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=174166; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Fetus: Morphology: Number of ribs; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605549_15605550_15605551:F:-fetus; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d73a18cb8d09538c2245ea15cfb6ca46
ToxValDB ECOTOX NOEC =0.04 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=302ffae0dc2a899a4ff94d048f6c570b
ToxValDB ECOTOX NOEC =34.5 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6341797210fbe5365030429f8d2d35f9
ToxValDB ECOTOX NOEC =38 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=81b1034ba6e7fadc71db7181c3283b42
ToxValDB ECOTOX NOEC =69 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ca7776183d309c56267078eb14b7f5df
ToxValDB ECOTOX NOEC =138 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2c9bfcf94b97b29ac675669e33771840
ToxValDB ECOTOX NOEC =152 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e551bbee782fe05dbbf73a59c85bef3d
ToxValDB ECOTOX NOEC =172.5 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e2729339993990244e9ca8fa01089be3
ToxValDB ECOTOX NOEC =276 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594670_15595124_15596352_15598188_15599122_15602239_15602728_15604240:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1990f9a5ef92f8a33b05c0886d3c3a55
ToxValDB ECOTOX NOEL =9.38 mmol/kg Rat oral acute; 0.75 days reproduction developmental LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595112_15598179_15604882_15604883:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=621514c665168f56c55ec2ed0069a72a
ToxValDB ECOTOX NOEL =400 mg/kg bw/day Mouse oral short-term; 11 days short-term LONG_REF=J. Biochem. Mol. Toxicol.17(6): 346-356 Kawanishi,C.Y., P. Hartig, K.L. Bobseine, J. Schmid, M. Cardon, G. Massenburg, and N. Chernoff Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development 2003; TITLE=Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development; AUTHOR=Kawanishi,C.Y., P. Hartig, K.L. Bobseine, J. Schmid, M. Cardon, G. Massenburg, and N. Chernoff; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=174166; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15594682:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c703f4d7f682082a0ab0a69debfcf8f3
ToxValDB ECOTOX NOEL =600 mg/kg bw/day Mouse oral short-term; 12 days short-term LONG_REF=J. Biochem. Mol. Toxicol.17(6): 346-356 Kawanishi,C.Y., P. Hartig, K.L. Bobseine, J. Schmid, M. Cardon, G. Massenburg, and N. Chernoff Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development 2003; TITLE=Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development; AUTHOR=Kawanishi,C.Y., P. Hartig, K.L. Bobseine, J. Schmid, M. Cardon, G. Massenburg, and N. Chernoff; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=174166; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15605552:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1adcec84810097ce7658d13555a04321
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 614OI1Z5WI UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"614OI1Z5WI"}
openFDA substances FDA UNII substance identifier 614OI1Z5WI UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"614OI1Z5WI"}
openFDA substances FDA UNII substance identifier 614OI1Z5WI UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"614OI1Z5WI"}
openFDA substances FDA UNII substance identifier 614OI1Z5WI UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"614OI1Z5WI"}